Evidence map›Paper›PMID 28210674›Full record

ArticleCellular and molecular gastroenterology and hepatology2015

IL33 Is a Stomach Alarmin That Initiates a Skewed Th2 Response to Injury and Infection.

Jon N Buzzelli, Heather V Chalinor, Daniel I Pavlic, Philip Sutton, Trevelyan R Menheniott, Andrew S Giraud, Louise M Judd

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 98 citations in OpenAlex.

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  13. Flavonoid-RichInternational journal of molecular sciences · 2023
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jon N BuzzelliMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, Victoria, Australia.
Heather V ChalinorMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Daniel I PavlicMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Philip SuttonMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Centre for Animal Biotechnology, School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia.
Trevelyan R MenheniottMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Andrew S GiraudMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, Victoria, Australia.
Louise M JuddMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia; Department of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, Victoria, Australia.
Royal Children's Hospital · AUUniversity of Melbourne · AUMurdoch Children's Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsInterleukin (IL)33 is a recently described alarmin that is highly expressed in the gastric mucosa and potently activates Th2 immunity. It may play a pivotal role during

methodsIL33 expression was evaluated in mice and human biopsy specimens infected with

resultsIn mice, the IL33 protein was localized to the nucleus of a subpopulation of surface mucus cells, and co-localized with the surface mucus cell markers Ulex Europaeus 1 (UEA1), and Mucin 5AC (Muc5AC). A small proportion of IL33-positive epithelial cells also were Ki-67 positive. IL33 and its receptor Interleukin 1 receptor-like 1 (ST2) were increased 4-fold after acute (1-day)

conclusionsIL33 is highly expressed in the gastric mucosa and promotes the activation of T helper 2-cytokine-expressing cells. The loss of IL33 expression after prolonged

Indexed as

AB, Alcian blueDC, dendritic cellELISA, enzyme-linked immunosorbent assayERK, extracellular signal–regulated kinaseFBS, fetal bovine serumGastric CancerHBSS, Hank’s balanced salt solutionHelicobacter pyloriIL33ILC, innate lymphoid cellIL, interleukinInflammatory ResponsemRNA, messenger RNANF-κB, nuclear factor-κBPAS, periodic acid–SchiffPCR, polymerase chain reactionQRT-PCR, quantitative reverse-transcription polymerase chain reactionSMC, surface mucus cellsSPF, specific pathogen freeSS1, Sydney strain 1STAT, signal transducer and activator of transcriptionTFF, trefoil factorTh, T-helperWT, wild type

Identifiers

PMID28210674
PMCPMC5301136
OpenAlexW1977119847

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.