Evidence map›Paper›PMID 28210524›Full record

ArticleInnovations in clinical neuroscience

Sympathetic Nerve Entrapment Point Injection as an Antireflux Procedure for Refractory Laryngopharyngeal Reflux: A First Case Report of Innovative Autonomic Regulation.

Sangsoo Lee, Chang Jin Oh, Jeong Won Seong

Open access · greenAbstract readCase Reports
In one paragraph

Article in Innovations in clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 71% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Autonomic dysfunction in laryngopharyngeal reflux: heart rate variability and its association with esophageal motility.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Transcutaneous electrical acupoint stimulation, autonomic nerve dysfunction and laryngopharyngeal reflux.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sangsoo LeeDr. Lee is with the Department of Psychiatry at Ahav Hospital, South Korea; Dr. Oh is with the Department of Pain Medicine and Anesthesiology at the Seoul Samsung Union Clinic in South Korea; and Dr. Seong is with the Department of Family Medicine at the SNEPI Research Institute, Sarang Clinic in South Korea.
Chang Jin OhDr. Lee is with the Department of Psychiatry at Ahav Hospital, South Korea; Dr. Oh is with the Department of Pain Medicine and Anesthesiology at the Seoul Samsung Union Clinic in South Korea; and Dr. Seong is with the Department of Family Medicine at the SNEPI Research Institute, Sarang Clinic in South Korea.
Jeong Won SeongDr. Lee is with the Department of Psychiatry at Ahav Hospital, South Korea; Dr. Oh is with the Department of Pain Medicine and Anesthesiology at the Seoul Samsung Union Clinic in South Korea; and Dr. Seong is with the Department of Family Medicine at the SNEPI Research Institute, Sarang Clinic in South Korea.
Dr Youth Clinic · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical treatment is not suitable for laryngopharyngeal reflux that is refractory to proton pump inhibitors. We present a case of proton pump inhibitor-refractory laryngopharyngeal reflux that was successfully treated with sympathetic nerve entrapment point injection. The patient had previously been diagnosed with laryngopharyngeal reflux and treated with proton pump inhibitors for six months without substantial improvement. After sympathetic nerve entrapment point injection treatment, her reflux symptom index improved from 15 points to 1 point, and this response was maintained for six months. Hyperexcitability of T5 and T6 sympathetic preganglionic fibers appears to be the main cause of laryngopharyngeal reflux. Sympathetic nerve entrapment point injection may represent an alternative to anti-reflux procedures.

Indexed as

antireflux procedureautonomic regulationlaryngopharyngeal refluxrefluxrefractorySympathetic nerve entrapment point injection

Identifiers

PMID28210524
PMCPMC5300710
OpenAlexW2902097188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.