ArticleThe western journal of emergency medicine2017
Intentional Recreational Abuse of Quetiapine Compared to Other Second-generation Antipsychotics.
Article in The western journal of emergency medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Analysing lithium, quetiapine and valproic acid on social media: an infodemiology study.International journal of bipolar disorders · 2025Article
- Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction.Biological psychiatry · 2025Article
- Prescription patterns of quetiapine for multiple drug abuse, depression, and psychosis: A retrospective study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Toxicity and Adverse Effects in Clozapine-Related Presentations to a Medical Toxicology Service in Western Sydney.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023Article
- Suspected inappropriate use of prescription and non-prescription drugs among requesting customers: A Saudi community pharmacists' perspective.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Quetiapine and olanzapine misuse prevalence in a US general population sample.The mental health clinician · 2023Article
- Antipsychotic Abuse, Dependence, and Withdrawal in the Pediatric Population: A Real-World Disproportionality Analysis.Biomedicines · 2022Article
- A Case Report of Excessive Use of Clozapine Combined With Clonazepam.Frontiers in psychiatry · 2022Article
- Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Acute Extrapyramidal Side Effects from Smoked Haloperidol.Case reports in psychiatry · 2021Article
- Characteristics of voluntary reporting of adverse drug events related to antipsychotics in Australia: 14-year analysis.Therapeutic advances in drug safety · 2021Article
- Quetiapine, Misuse and Dependency: A Case-Series of Questions to a Norwegian Network of Drug Information Centers.Drug, healthcare and patient safety · 2021Article
- Focus on Clozapine Withdrawal- and Misuse-Related Cases as Reported to the European Medicines Agency (EMA) Pharmacovigilance Database.Brain sciences · 2020Article
- Acute poisoning related to the recreational use of prescription drugs: an observational study from Oslo, Norway.BMC emergency medicine · 2019Observational
- Comparison of Quetiapine Abuse and Misuse Reports to the FDA Adverse Event Reporting System With Other Second-Generation Antipsychotics.Substance abuse : research and treatment · 2019Article
- Abuse of Prescription Drugs in the Context of Novel Psychoactive Substances (NPS): A Systematic Review.Brain sciences · 2018Review
- Convulsive syncope related to a small dose of quetiapine in an adolescent with bipolar disorder.Neuropsychiatric disease and treatment · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCase reports and poison center data have demonstrated that the second-generation antipsychotic quetiapine is being obtained and used for recreational abuse. The purpose of this study was to describe the relative rates of single-substance abuse for different atypical antipsychotics and compare their demographic and clinical features.
methodsWe conducted a 10-year retrospective analysis of the National Poison Data System (NPDS) database (2003 - 2013). Trained nurses and pharmacists with specialty training in toxicology prospectively collect all NPDS data at poison control centers around the United States. We queried the NPDS for all cases of single-substance second-generation antipsychotic exposures coded as "intentional abuse." The data provided by the NPDS regarding rates and clinical features of quetiapine abuse and the abuse of all other second-generation antipsychotics were compared and described descriptively.
resultsDuring the study period, 2,118 cases of quetiapine abuse and 1,379 cases of other second-generation antipsychotic abuse were identified. Quetiapine abuse was more common than the abuse of other second-generation antipsychotics, compromising 60.6% of all abuse cases during the study period. After quetiapine, the next most frequently abused medications were risperidone (530 cases, 15.2%) and olanzapine (246 cases, 7.0%). For all second-generation antipsychotics including quetiapine, central nervous system clinical effects were most common, including drowsiness, confusion, and agitation. Other serious clinical effects observed with second-generation antipsychotic abuse included hypotension, respiratory depression, and seizures.
conclusionQuetiapine abuse is relatively common, and is abused far more often than any other second-generation antipsychotic. Emergency physicians should be aware of the clinical effects that may occur after second-generation antipsychotic abuse.
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Registered trials
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