ArticleFrontiers in microbiology2017
Feeding a High Concentration Diet Induces Unhealthy Alterations in the Composition and Metabolism of Ruminal Microbiota and Host Response in a Goat Model.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 107 citations in OpenAlex.
- Yeast Culture Alleviates High-Concentrate Diet-Induced Rumen Fermentation Disturbances and Modulates the Rumen Microbiota and Metabolome in Lambs.Microorganisms · 2026Article
- The Dietary Inclusion of Corn and Peas Affects the Fecal Bacterial Diversity and Composition of Sarda Goats.Animals : an open access journal from MDPI · 2026Article
- Intestinal Alkaline Phosphatase Alleviates Ruminal Acidosis in Dairy Cows Fed High-Concentrate Diets Improves Their Overall Health.Journal of animal physiology and animal nutrition · 2026Article
- Cornus officinalis extract modulates rumen microbiome and growth of lambs fed a high-concentrate diet.AMB Express · 2026Article
- Effects of Left-Displaced Abomasum on the Rumen Microbiota of Dairy Cows.Microorganisms · 2025Article
- Dietary energy levels modulate rumen metabolites and function in sheep by regulating the rumen microbiome.BMC microbiology · 2025Article
- Microbiota-Metabolite-Host Crosstalk Mediates the Impact of Dietary Energy Levels on Colonic Homeostasis in High-Altitude Ruminants.Animals : an open access journal from MDPI · 2025Article
- Supplementation with Rare Earth-Chitosan Chelate Improves Tibia Quality, Disease Resistance Capacity, and Performance in Nursery Pigs.International journal of molecular sciences · 2025Article
- Host-driven remodeling of rumen microbiota supports lactation metabolism in buffalo.Frontiers in microbiology · 2025Article
- Comparative analysis of cecal microbiota and metabolites in relation to growth performance of Tibetan and Hu sheep.Frontiers in microbiology · 2025Article
- Article
- Investigation into Critical Gut Microbes Influencing Intramuscular Fat Deposition in Min Pigs.Animals : an open access journal from MDPI · 2024Article
- Differences in Lactation Performance, Rumen Microbiome, and Metabolome between Montbéliarde × Holstein and Holstein Cows under Heat Stress.Microorganisms · 2024Article
- Integrating 16S rRNA Sequencing and LC-MS-Based Metabolomics to Evaluate the Effects of Dietary Crude Protein on Ruminal Morphology, Fermentation Parameter and Digestive Enzyme Activity in Tibetan Sheep.Animals : an open access journal from MDPI · 2024Article
- Lyophilized rumen fluid as a ruminal fermentation modifier in high grain-fed acidotic goats.Tropical animal health and production · 2024Article
- Disturbances of Ruminal Microbiota and Liver Inflammation, Mediated by LPS and Histamine, in Dairy Cows Fed a High-Concentrate Diet.Animals : an open access journal from MDPI · 2024Article
- Assessing the impact of three feeding stages on rumen bacterial community and physiological characteristics of Japanese Black cattle.Scientific reports · 2024Article
- High concentrate diets altered the structure and function of rumen microbiome in goats.Frontiers in microbiology · 2024Article
- Effects ofFrontiers in microbiology · 2024Article
- Intestinal Microbiota Community and Blood Fatty Acid Profiles of Albas Cashmere Goats Fed with Flaxseed Oil and Whole Flaxseed.Animals : an open access journal from MDPI · 2023Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is limited knowledge about the impact of long-term feeding a high-concentrate (HC) diet on rumen microbiota, metabolome, and host cell functions. In this study, a combination of mass spectrometry-based metabolomics techniques, 454 pyrosequencing of 16S rDNA genes, and RT-PCR was applied to evaluate the changes of ruminal microbiota composition, ruminal metabolites, and related genes expression in rumen epithelial cells of lactating goats received either a 35% concentrate diet or a 65% concentrate diet for 4 or 19 weeks, respectively. Results show that feeding a HC diet reduced the microbiota diversity and led to the disorders of metabolism in the rumen. The concentrations of lactate, phosphorus, NH3-N and endotoxin Lipopolysaccharide in ruminal fluids, and plasma histamine, lactate and urine N (UN) were increased significantly in goats fed with a HC diet. A significant increase of genes expression related to volatile fatty acids transport, cell apoptosis, and inflammatory responses were also observed in goats fed with a HC diet. Correlation analysis revealed some potential relationships between bacteria abundance and metabolites concentrations. Our findings indicate that a HC diet can induce ruminal microbiota dysbiosis and metabolic disorders, thus increasing risks to host health and potential harm to the environment.
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