Evidence map›Paper›PMID 28210219›Full record

ArticleFrontiers in synaptic neuroscience2017

Mice Lacking M1 and M3 Muscarinic Acetylcholine Receptors Have Impaired Odor Discrimination and Learning.

Wilson Chan, Sanmeet Singh, Taj Keshav, Ramita Dewan, Christian Eberly, Robert Maurer, Alexia Nunez-Parra, Ricardo C Araneda

Open access · goldAbstract read
In one paragraph

Article in Frontiers in synaptic neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026
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  11. Rigor and reproducibility in rodent behavioral research.Neurobiology of learning and memory · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Wilson ChanDepartment of Biology, University of Maryland College Park, MD, USA.
Sanmeet SinghDepartment of Biology, University of Maryland College Park, MD, USA.
Taj KeshavDepartment of Biology, University of Maryland College Park, MD, USA.
Ramita DewanDepartment of Biology, University of Maryland College Park, MD, USA.
Christian EberlyDepartment of Biology, University of Maryland College Park, MD, USA.
Robert MaurerDepartment of Biology, University of Maryland College Park, MD, USA.
Alexia Nunez-ParraInstituto de Ciencias Biomédicas, Universidad Autónoma de Chile Santiago, Chile.
Ricardo C AranedaDepartment of Biology, University of Maryland College Park, MD, USA.
University of Maryland, College Park · USUniversidad Autónoma de Chile · CL

Funding

Neuromodulation in the olfactory systemR01DC009817 · NIDCD · UNIV OF MARYLAND, COLLEGE PARK · PI ARANEDA, RICARDO C · 2010 to 2014
$1.8M
NIDCD NIH HHS R01 DC009817
6 · The paper itself

Abstract

The cholinergic system has extensive projections to the olfactory bulb (OB) where it produces a state-dependent regulation of sensory gating. Previous work has shown a prominent role of muscarinic acetylcholine (ACh) receptors (mAChRs) in regulating the excitability of OB neurons, in particular the M1 receptor. Here, we examined the contribution of M1 and M3 mAChR subtypes to olfactory processing using mice with a genetic deletion of these receptors, the M1

Indexed as

adult neurogenesisgranule cellinhibitionolfactoryolfactory discrimination

Identifiers

PMID28210219
PMCPMC5288360
OpenAlexW2584459461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.