Evidence map›Paper›PMID 28210202›Full record

ArticleDose-response : a publication of International Hormesis Society

Mechanisms and Effects of Transcranial Direct Current Stimulation.

James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley and 5 more

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 95 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04000269 nawithdrawnnot on this map

Pilot Study Using Targeted High Definition Transcranial Direct Current Stimulation to Promote Upper Extremity Motor Function in Patients With Subacute Middle Cerebral Artery (MCA) Stroke

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2020 to 2022Enrolled0ConditionsMiddle Cerebral Artery StrokeArmsSoterix MxN Neuromodulation device, Sham Stimulation
NCT04010149 naunknown statusnot on this map

The Impact of Concurrent Brain Stimulation and Working Memory Training on Cognitive Performance in Acquired Brain Injury

TypeinterventionalSponsorUniversity of BirminghamRan2019 to 2021Enrolled40ConditionsAcquired Brain InjuryArmsActive tDCS, SHAM tDCS
NCT07410104 narecruitingnot on this map

Impact of Non-Invasive Neuromodulation on Social Media Addiction

TypeinterventionalSponsorEgas Moniz - Cooperativa de Ensino Superior, CRLRan2026 to 2026Enrolled60ConditionsSocial Media Addiction, Craving to Use Social Media, Craving, Internet AddictionArmsTranscranial Direct Current Stimulation (tDCS), Sham Transcranial Direct Current Stimulation (Sham tDCS)
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  15. [Research on enhancement of mental rotation ability based on transcranial direct current stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

James GiordanoDepartment of Neurology and Biochemistry, Neuroethics Studies Program, Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center, Washington, DC, USA.
Marom BiksonBiomedical Engineering, City College of New York, CUNY, New York, NY, USA.
Emily S KappenmanSan Diego State University, Department of Psychology, San Diego, CA, USA.
Vincent P ClarkPsychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, NM, USA.
H Branch CoslettDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital and Department of Dermatology, Harvard Medical School, Boston, MA, USA.
Roy HamiltonDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ryan JankordUnited States Air Force Research Laboratory, Wright-Patterson Air Force Base, OH, USA.
Walter J KozumboHormesis Project, University of Massachusetts, Amherst, MA, USA.
R Andrew McKinleyUnited States Air Force Research Laboratory, Wright-Patterson Air Force Base, OH, USA.
Michael A NitscheDepartment Psychology and Neurosciences, Leibniz Research Center for Working Environmental and Human Factors, Dortmund, Germany.
J Patrick ReillyMetatec Associates, Silver Spring, MD, USA.
Jessica RichardsonDepartment of Speech and Hearing Sciences, University of New Mexico, Albuquerque, NM, USA.
Rachel WurzmanDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Edward CalabreseEnvironmental Health Sciences, University of Massachusetts, Amherst, MA, USA.

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Training and Career Development CoreU54CA132378 · NCI · CITY COLLEGE OF NEW YORK · PI Tim Alan Ahles, ADRIANA ESPINOSA · 2008 to 2026
$28.9M
Training and Career Development and Education CoreU54CA137788 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADRIANA ESPINOSA, FRANCESCA M GANY · 2008 to 2026
$28.1M
University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Temporal dynamics of neurophysiological patterns as treatment targets in SzR01MH109289 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI JAVITT, DANIEL C. · 2016 to 2020
$3.7M
A tool-box to control and enhance tDCS spatial precisionR01MH111896 · NIMH · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2016 to 2019
$2.2M
Effects of direct-current stimulation on synaptic plasticityR01NS095123 · NINDS · CITY COLLEGE OF NEW YORK · PI PARRA, LUCAS C · 2016 to 2020
$1.7M
NCATS NIH HHS UL1 TR001409NCI NIH HHS U54 CA132378NCI NIH HHS U54 CA137788NIGMS NIH HHS P20 GM109089NIMH NIH HHS R01 MH109289NIMH NIH HHS R01 MH111896NINDS NIH HHS R01 NS095123
6 · The paper itself

Abstract

The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research. Scientific, medical, and ethical considerations support the ongoing testing of tDCS in healthy and clinical populations, provided best protocols are used to maximize safety. Notwithstanding the need for ongoing research, promising applications include enhancing vigilance/attention in healthy volunteers, which can accelerate training and support learning. Commonly, tDCS is used as an adjunct to training/rehabilitation tasks with the goal of leftward shift in the learning/treatment effect curves. Although trials are encouraging, elucidating the basic mechanisms of tDCS will accelerate validation and adoption. To this end, biomarkers (eg, clinical neuroimaging and findings from animal models) can support hypotheses linking neurobiological mechanisms and behavioral effects. Dosage can be optimized using computational models of current flow and understanding dose-response. Both biomarkers and dosimetry should guide individualized interventions with the goal of reducing variability. Insights from other applied energy domains, including ionizing radiation, transcranial magnetic stimulation, and low-level laser (light) therapy, can be prudently leveraged.

Indexed as

biphasicdose–responseelectrical stimulationhormesishormetictDCS

Identifiers

PMID28210202
PMCPMC5302097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.