Evidence map›Paper›PMID 28210133›Full record

ArticleLung Cancer (Auckland, N.Z.)2013

Robotic stereotactic body radiation therapy for elderly medically inoperable early-stage non-small cell lung cancer.

Sana D Karam, Zachary D Horne, Robert L Hong, Nimrah Baig, Gregory J Gagnon, Don McRae, David Duhamel, Nadim M Nasr

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung Cancer (Auckland, N.Z.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sana D KaramDepartment of Radiation Oncology, Georgetown University Hospital, Washington, DC, USA.
Zachary D HorneDepartment of Radiation Oncology, Georgetown University Hospital, Washington, DC, USA.
Robert L HongDepartment of Radiation Oncology, Georgetown University Hospital, Washington, DC, USA; Department of Radiation Oncology, Virginia Hospital Center, Arlington, VA, USA.
Nimrah BaigDepartment of Radiation Oncology, Georgetown University Hospital, Washington, DC, USA.
Gregory J GagnonDepartment of Radiation Oncology, Frederick Memorial Hospital, Frederick, MD, USA.
Don McRaeDepartment of Radiation Oncology, Virginia Hospital Center, Arlington, VA, USA.
David DuhamelDepartment of Pulmonary/Critical Care Medicine, Virginia Hospital Center, Arlington, VA, USA.
Nadim M NasrDepartment of Radiation Oncology, Georgetown University Hospital, Washington, DC, USA; Department of Radiation Oncology, Virginia Hospital Center, Arlington, VA, USA.
Virginia Hospital Center · USCalvert Memorial Hospital · USGeorgetown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionStereotactic body radiation therapy (SBRT) is being increasingly applied in the treatment of non-small cell lung cancer (NSCLC) because of its high local efficacy. This study aims to examine survival outcomes in elderly patients with inoperable stage I NSCLC treated with SBRT.

methodsA total of 31 patients with single lesions treated with fractionated SBRT from 2008 to 2011 were retrospectively analyzed. A median prescribed dose of 48 Gy was delivered to the prescription isodose line, over a median of four treatments. The median biologically effective dose (BED) was 105.6 (range 37.50-180), and the median age was 73 (65-90 years). No patient received concurrent chemotherapy.

resultsWith a median follow up of 13 months (range, 4-40 months), the actuarial median overall survival (OS) and progression-free survival (PFS) were 32 months, and 19 months, respectively. The actuarial median local control (LC) time was not reached. The survival outcomes at median follow up of 13 months were 80%, 68%, and 70% for LC, PFS, and OS, respectively. Univariate analysis revealed a BED of >100 Gy was associated with improved LC rates (

conclusionSBRT is a safe, feasible, and effective treatment option for elderly patients with inoperable early stage NSCLC. BED, histology, and tumor size are predictors of local control, while tumor size and gender predict OS.

Indexed as

BEDCyberKnifegenderhistologySABR

Identifiers

PMID28210133
PMCPMC5217439
OpenAlexW2130345430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.