Evidence map›Paper›PMID 28210078›Full record

ArticleWorld journal of gastroenterology2017

Sex differences and effects of oestrogen in rat gastric mucosal defence.

Richard Shore, Håkan Björne, Yoko Omoto, Anna Siemiatkowska, Jan-Åke Gustafsson, Mats Lindblad, Lena Holm

Open access · hybridAbstract readComparative Study
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Use ofPeerJ · 2024
    Article
  5. Article
  6. Sex differences feed into nuclear receptor signaling along the digestive tract.Biochimica et biophysica acta. Molecular basis of disease · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Gastroduodenal Injury: Role of Protective Factors.Current gastroenterology reports · 2019
    Review
  11. Article
  12. Preventive Effect ofFoods (Basel, Switzerland) · 2019
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Richard ShoreRichard Shore, Mats Lindblad, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, S-14186 Stockholm, Sweden.
Håkan BjörneRichard Shore, Mats Lindblad, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, S-14186 Stockholm, Sweden.
Yoko OmotoRichard Shore, Mats Lindblad, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, S-14186 Stockholm, Sweden.
Anna SiemiatkowskaRichard Shore, Mats Lindblad, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, S-14186 Stockholm, Sweden.
Jan-Åke GustafssonRichard Shore, Mats Lindblad, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, S-14186 Stockholm, Sweden.
Mats LindbladRichard Shore, Mats Lindblad, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, S-14186 Stockholm, Sweden.
Lena HolmRichard Shore, Mats Lindblad, Department of Clinical Sciences, Intervention and Technology (CLINTEC), Karolinska Institutet, S-14186 Stockholm, Sweden.
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate sex differences and the effects of oestrogen administration in rat gastric mucosal defence.

methodsSex differences in gastric mucus thickness and accumulation rate, absolute gastric mucosal blood flow using microspheres, the integrity of the gastric mucosal epithelium in response to a chemical irritant and the effects of oestrogen administration on relative gastric mucosal blood flow in an acute setting was assessed in an

resultsThe absolute blood flow in the GI-tract was generally higher in males, but only significantly different in the corpus part of the stomach (1.12 ± 0.12 mL/min•g in males and 0.51 ± 0.03 mL/min•g in females) (

conclusionGastric mucosal blood flow is higher in male than in female rats and is reduced in male rats by oestrogen administration.

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCalcitonin Gene-Related PeptideDiclofenacEpitheliumEstradiolEstrogensFemaleGastric MucosaMaleModels, AnimalPermeabilityRatsRats, Sprague-DawleyReceptors, EstrogenSex FactorsAnti-Inflammatory Agents, Non-SteroidalCalcitonin Gene-Related PeptideDiclofenacEstradiolEstrogensReceptors, EstrogenTaurocholic AcidBlood flowGastric mucosal defenceGastric physiologyMucusOestrogenSex differences

Identifiers

PMID28210078
PMCPMC5291847
OpenAlexW2587526124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.