ArticleMediators of inflammation2017
The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression.
Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review.Frontiers in cellular and infection microbiology · 2024Review
- The Variable Nature of Vitamin C-Does It Help When Dealing with Coronavirus?Antioxidants (Basel, Switzerland) · 2022Review
- Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats.Scientific reports · 2021Article
- Spices, Condiments, Extra Virgin Olive Oil and Aromas as Not Only Flavorings, but Precious Allies for Our Wellbeing.Antioxidants (Basel, Switzerland) · 2021Review
- Overview of the possible role of vitamin C in management of COVID-19.Pharmacological reports : PR · 2020Review
- Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial.BMJ open · 2020Article
- Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir.Journal of critical care · 2020Review
- A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain.Nutrients · 2020Article
- Vitamin C: an essential "stress hormone" during sepsis.Journal of thoracic disease · 2020Review
- Retracted: Neuropilin-1Mediators of inflammation · 2020Article
- Retracted: The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression.Mediators of inflammation · 2020Article
- Effectiveness of fecal microbiota transplantation for severe diarrhea after drug-induced hypersensitivity syndrome.Medicine · 2019Article
- Immunomodulatory and Antimicrobial Effects of Vitamin C.European journal of microbiology & immunology · 2019Review
- Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis.Annals of intensive care · 2019Review
- Vitamin C in the critically ill - indications and controversies.World journal of critical care medicine · 2018Review
- Vitamin C: should we supplement?Current opinion in critical care · 2018Review
- Correlation analysis of omega-3 fatty acids and mortality of sepsis and sepsis-induced ARDS in adults: data from previous randomized controlled trials.Nutrition journal · 2018Review
- Influence of Vitamin C on Lymphocytes: An Overview.Antioxidants (Basel, Switzerland) · 2018Review
- Recent Advances in the Molecular Mechanisms Underlying Pyroptosis in Sepsis.Mediators of inflammation · 2018Review
- Vitamin C and Immune Function.Nutrients · 2017Review
Corrections and comments
- Retraction · 2020-09-04Duplication of/in Image · Investigation by Third Party · Original Data and/or Images not Provided and/or not Available · · See also: https://pubpeer.com/publications/5EB78957D481A43893D38764FB3118
- Retracted
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular immunosuppression appears to be involved in sepsis and sepsis-induced multiple organ dysfunction syndrome (MODS). Recent evidence showed that parenteral vitamin C (Vit C) had the ability to attenuate sepsis and sepsis-induced MODS. Herein, we investigated the impact of parenteral Vit C on cellular immunosuppression and the therapeutic value in sepsis. Using cecal ligation and puncture (CLP), sepsis was induced in WT and Gulo
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.