ArticleScientific reports2017
Severe Decline of Estimated Glomerular Filtration Rate Associates with Progressive Cognitive Deterioration in the Elderly: A Community-Based Cohort Study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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14 citing papers in PubMed, 31 citations in OpenAlex.
- Kidney Function, Cognitive Impairment, and Trajectories: A Longitudinal Biracial Study.Journal of general internal medicine · 2025Article
- Common mental disorders and associated factors among adult chronic kidney disease patients attending referral hospitals in Amhara Regional State.Scientific reports · 2024Article
- Current Status of the Cognitive Impairment in Chronic Kidney Disease.Physical therapy research · 2024Review
- Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank.BMC nephrology · 2022Article
- Cognitive impairment in patients with moderate to severe chronic kidney disease: the Salford kidney cohort study.Clinical kidney journal · 2021Article
- Trajectory of Estimated Glomerular Filtration Rate and Malnourishment Predict Mortality and Kidney Failure in Older Adults With Chronic Kidney Disease.Frontiers in medicine · 2021Article
- Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study.Neuropsychiatric disease and treatment · 2021Article
- Markers of Kidney Function and Longitudinal Cognitive Ability Among Older Community-Dwelling Adults: The Rancho Bernardo Study.Journal of Alzheimer's disease : JAD · 2021Article
- Renal dysfunction is associated with decline of cognitive function in community-dwelling older adults: Korean frailty and aging cohort study.BMC geriatrics · 2020Article
- Prediction of Nephrotoxicity Associated With Cisplatin-Based Chemotherapy in Testicular Cancer Patients.JNCI cancer spectrum · 2020Article
- Role of prognostic biomarker decoy receptor 3 and immunomodulation in kidney diseases.Journal of the Chinese Medical Association : JCMA · 2019Review
- The assessment of cognitive function in older adult patients with chronic kidney disease: an integrative review.Journal of nephrology · 2019Review
- Association between health behaviors and mood disorders among the elderly: a community-based cohort study.BMC geriatrics · 2019Article
- Risk Factors for Declines in Kidney Function in Sugarcane Workers in Guatemala.Journal of occupational and environmental medicine · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive dysfunction is closely related to aging and chronic kidney disease (CKD). However, the association between renal function changes and the risk of developing cognitive impairment has not been elucidated. This longitudinal cohort study was to determine the influence of annual percentage change in estimated glomerular filtration rate (eGFR) on subsequent cognitive deterioration or death of the elderly within the community. A total of 33,654 elders with eGFR measurements were extracted from the Taipei City Elderly Health Examination Database. The Short Portable Mental Status Questionnaire was used to assess their cognitive progression at least twice during follow-up visits. Multivariable Cox regression models were used to estimate the hazard ratio (HR) for cognitive deterioration or all-cause mortality with the percentage change in eGFR. During a median follow-up of 5.4 years, the participants with severe decline in eGFR (>20% per year) had an increased risk of cognitive deterioration (HR, 1.33; 95% confidence interval [CI], 1.08-1.72) and the composite outcome (HR, 1.17; 95% CI, 1.03-1.35) when compared with those who had stable eGFR. Severe eGFR decline could be a possible predictor for cognitive deterioration or death among the elderly. Early detection of severe eGFR decline is a critical issue and needs clinical attentions.
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