ArticleScientific reports2017
High-amplitude electrical stimulation can reduce elicited neuronal activity in visual prosthesis.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Bilateral retinal implants for improving visual restoration: a simulated bionic vision study.Medical & biological engineering & computing · 2026Article
- Cyborg insect factory: automatic assembly for insect-computer hybrid robot via vision-guided robotic arm manipulation of custom bipolar electrodes.Nature communications · 2025Article
- An arbitrary waveform neurostimulator for preclinical studies: design and verification.Medical & biological engineering & computing · 2025Article
- Implications of Neural Plasticity in Retinal Prosthesis.Investigative ophthalmology & visual science · 2022Article
- Opposite Roles of NT-3 and BDNF in Synaptic Remodeling of the Inner Ear Induced by Electrical Stimulation.Cellular and molecular neurobiology · 2021Article
- Stimulation Strategies for Improving the Resolution of Retinal Prostheses.Frontiers in neuroscience · 2020Review
- Editorial: A Conversation With the Brain: Can We Speak Its Language?Frontiers in neuroscience · 2020Article
- Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis.Scientific reports · 2019Article
- Mediating Retinal Ganglion Cell Spike Rates Using High-Frequency Electrical Stimulation.Frontiers in neuroscience · 2019Article
- Response of Mouse Visual Cortical Neurons to Electric Stimulation of the Retina.Frontiers in neuroscience · 2019Article
- Visual prostheses, optogenetics, stem cell and gene therapies: splitting the cake.Neural regeneration research · 2018Article
- Closed-Loop Efficient Searching of Optimal Electrical Stimulation Parameters for Preferential Excitation of Retinal Ganglion Cells.Frontiers in neuroscience · 2018Article
- Visual Prosthesis: Interfacing Stimulating Electrodes with Retinal Neurons to Restore Vision.Frontiers in neuroscience · 2017Review
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal electrostimulation is promising a successful therapy to restore functional vision. However, a narrow stimulating current range exists between retinal neuron excitation and inhibition which may lead to misperformance of visual prostheses. As the conveyance of representation of complex visual scenes may require neighbouring electrodes to be activated simultaneously, electric field summation may contribute to reach this inhibitory threshold. This study used three approaches to assess the implications of relatively high stimulating conditions in visual prostheses: (1) in vivo, using a suprachoroidal prosthesis implanted in a feline model, (2) in vitro through electrostimulation of murine retinal preparations, and (3) in silico by computing the response of a population of retinal ganglion cells. Inhibitory stimulating conditions led to diminished cortical activity in the cat. Stimulus-response relationships showed non-monotonic profiles to increasing stimulating current. This was observed in vitro and in silico as the combined response of groups of neurons (close to the stimulating electrode) being inhibited at certain stimulating amplitudes, whilst other groups (far from the stimulating electrode) being recruited. These findings may explain the halo-like phosphene shapes reported in clinical trials and suggest that simultaneous stimulation in retinal prostheses is limited by the inhibitory threshold of the retinal ganglion cells.
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Registered trials
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