Evidence map›Paper›PMID 28209899›Full record

ArticleScience (New York, N.Y.)2017

GTPase activity-coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis.

Xinxing Yang, Zhixin Lyu, Amanda Miguel, Ryan McQuillen, Kerwyn Casey Huang, Jie Xiao

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 283 papers.

0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

283 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Devising a divisome for synthetic cells.Nature reviews. Chemistry · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Extensile Active Hydrogels Driven by Living FtsZ Polymers.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  14. Sensing the shape of a surface by tightly surface-bound filaments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Conformational regulation of two essential activators of bacterial cell elongation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Peptidoglycan polymerase function and regulation.Microbiology and molecular biology reviews : MMBR · 2025
    Review

223 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xinxing YangDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2101-9881
Zhixin LyuDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7668-614X
Amanda MiguelDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-2750-4842
Ryan McQuillenDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-0399-5248
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA. kchuang@stanford.edu xiao@jhmi.edu.ORCID 0000-0002-8043-8138
Jie XiaoDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. kchuang@stanford.edu xiao@jhmi.edu.ORCID 0000-0003-1433-5437

Funding

PROGRAM IN MOLECULAR BIOPHYSICST32GM008403 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BARRICK, DOUGLAS E. · 1990 to 2019
$13.5M
TRAINING & OUTREACH COREP50GM107615 · NIGMS · STANFORD UNIVERSITY · PI FERRELL, JAMES E. · 2013 to 2017
$10.9M
Probing the structure, dynamics and function of the E. coli divisomeR01GM086447 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI XIAO, JIE · 2011 to 2019
$3.8M
Engineering of cell shape and intracellular organizationDP2OD006466 · OD · STANFORD UNIVERSITY · PI HUANG, KERWYN C. · 2009 to 2009
$2.4M
NIGMS NIH HHS P50 GM107615NIGMS NIH HHS R01 GM086447NIGMS NIH HHS T32 GM008403NIH HHS DP2 OD006466
6 · The paper itself

Abstract

The bacterial tubulin FtsZ is the central component of the cell division machinery, coordinating an ensemble of proteins involved in septal cell wall synthesis to ensure successful constriction. How cells achieve this coordination is unknown. We found that in

Indexed as

Bacterial ProteinsCell WallCytoskeletal ProteinsEscherichia coliGTP PhosphohydrolasesHydrolysisMutationPeptidoglycanTubulinBacterial ProteinsCytoskeletal ProteinsFtsZ protein, BacteriaGTP PhosphohydrolasesPeptidoglycanTubulin

Identifiers

PMID28209899
PMCPMC5851775

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.