ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017
Methyl donor supplementation alters cognitive performance and motivation in female offspring from high-fat diet-fed dams.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Choline supplementation partially reverses prefrontal neurochemical deficits induced by perinatal opioid exposure.Scientific reports · 2026Article
- Peri- and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice.Aging cell · 2025Article
- Epigenetic landscape in lysosomal storage disorders: mechanisms and modulation.Frontiers in genetics · 2025Review
- A novel role for phospholamban in the thalamic reticular nucleus.Scientific reports · 2024Article
- Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice.Neurotoxicology · 2023Article
- Maternal thyroid hormone receptor β activation in mice sparks brown fat thermogenesis in the offspring.Nature communications · 2023Article
- Early life cancer and chemotherapy lead to cognitive deficits related to alterations in microglial-associated gene expression in prefrontal cortex.Brain, behavior, and immunity · 2023Article
- Sex Differences in Neurodevelopmental Disorders: A Key Role for the Immune System.Current topics in behavioral neurosciences · 2023Article
- Article
- Dietary Choline Mitigates High-Fat Diet-Impaired Chylomicrons Assembly via UPRer Modulated byCells · 2022Article
- Impact of Maternal Obesity on the Gestational Metabolome and Infant Metabolome, Brain, and Behavioral Development in Rhesus Macaques.Metabolites · 2022Article
- Improving translational relevance: The need for combined exposure models for studying prenatal adversity.Brain, behavior, & immunity - health · 2021Article
- Review
- Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA).International journal of molecular sciences · 2020Article
- Complex epigenetic patterns in cerebellum generated after developmental exposure to trichloroethylene and/or high fat diet in autoimmune-prone mice.Environmental science. Processes & impacts · 2020Article
- Adolescent microglia play a role in executive function in male mice exposed to perinatal high fat diet.Brain, behavior, and immunity · 2020Article
- A high methyl donor diet affects physiology and behavior in Peromyscus polionotus.Physiology & behavior · 2019Article
- Effect of supplementation with methyl-donor nutrients on neurodevelopment and cognition: considerations for future research.Nutrition reviews · 2018Review
- Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain.Journal of neurochemistry · 2018Article
- Housing and testing in mixed-sex rooms increases motivation and accuracy during operant testing in both male and female mice.Neurobiology of learning and memory · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
During gestation, fetal nutrition is entirely dependent on maternal diet. Maternal consumption of excess fat during pregnancy has been linked to an increased risk of neurologic disorders in offspring, including attention deficit/hyperactivity disorder, autism, and schizophrenia. In a mouse model, high-fat diet (HFD)-fed offspring have cognitive and executive function deficits as well as whole-genome DNA and promoter-specific hypomethylation in multiple brain regions. Dietary methyl donor supplementation during pregnancy or adulthood has been used to alter DNA methylation and behavior. Given that extensive brain development occurs during early postnatal life-particularly within the prefrontal cortex (PFC), a brain region critical for executive function-we examined whether early life methyl donor supplementation (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.