Evidence map›Paper›PMID 28209730›Full record

ArticleMolecular biology of the cell2017

Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane.

David B Iaea, Shu Mao, Frederik W Lund, Frederick R Maxfield

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. CaAdvances in experimental medicine and biology · 2023
    Article
  9. Article
  10. [Steroidogenic acute regulatory protein-related lipid transfer 4 (StarD4) promotes breast cancer cell proliferation and its mechanism].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
    Article
  11. The Sterol Trafficking Pathway inFrontiers in plant science · 2021
    Article
  12. Review
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

David B IaeaDepartment of Biochemistry, Weill Cornell Medical College, New York, NY 10065.
Shu MaoDepartment of Biochemistry, Weill Cornell Medical College, New York, NY 10065.
Frederik W LundDepartment of Biochemistry, Weill Cornell Medical College, New York, NY 10065.
Frederick R MaxfieldDepartment of Biochemistry, Weill Cornell Medical College, New York, NY 10065 frmaxfie@med.cornell.edu.
Cornell University · USMemorial Sloan Kettering Cancer Center · US

Funding

RECEPTOR-MEDIATED ENDOCYTOSIS: MECHANISM AND FUNCTIONR37DK027083 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI MAXFIELD, FREDERICK R. · 1993 to 2014
$6.5M
Intracellular Cholesterol TransportR01GM123462 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MAXFIELD, FREDERICK R. · 2018 to 2021
$1.4M
Structure-function studies of the sterol transport protein, STARD4.F31DK104631 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI IAEA, DAVID BURTON · 2015 to 2016
$69k
NIDDK NIH HHS F31 DK104631NIDDK NIH HHS R37 DK027083NIGMS NIH HHS R01 GM123462
6 · The paper itself

Abstract

Cholesterol is an essential constituent of membranes in mammalian cells. The plasma membrane and the endocytic recycling compartment (ERC) are both highly enriched in cholesterol. The abundance and distribution of cholesterol among organelles are tightly controlled by a combination of mechanisms involving vesicular and nonvesicular sterol transport processes. Using the fluorescent cholesterol analogue dehydroergosterol, we examined sterol transport between the plasma membrane and the ERC using fluorescence recovery after photobleaching and a novel sterol efflux assay. We found that sterol transport between these organelles in a U2OS cell line has a

Indexed as

AnimalsBiological TransportCell Line, TumorCell MembraneCholesterolEndocytosisEndosomesErgosterolHumansMembrane Transport ProteinsSheepSterolsCholesteroldehydroergosterolErgosterolMembrane Transport ProteinsSTARD4 protein, humanSterols

Identifiers

PMID28209730
PMCPMC5391187
OpenAlexW2588279120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.