Evidence map›Paper›PMID 28209720›Full record

ArticleBlood2017

Acquired expression of

Yuichiro Nakata, Takeshi Ueda, Akiko Nagamachi, Norimasa Yamasaki, Ken-Ichiro Ikeda, Yasuyuki Sera, Keiyo Takubo, Akinori Kanai, Hideaki Oda, Masashi Sanada and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. MBTD1 preserves adult hematopoietic stem cell pool size and function.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Review
  9. Mouse Models of CMML.International journal of molecular sciences · 2021
    Review
  10. Molecular pathogenesis of the myeloproliferative neoplasms.Journal of hematology & oncology · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. ModelingBlood · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 3 countries.

Yuichiro NakataDepartment of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Takeshi UedaDepartment of Biochemistry, Faculty of Medicine, Kindai University, Osaka, Japan.
Akiko NagamachiDepartment of Molecular Oncology, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Norimasa YamasakiDepartment of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Ken-Ichiro IkedaDepartment of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Yasuyuki SeraDepartment of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Keiyo TakuboDepartment of Stem Cell Biology, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Akinori KanaiDepartment of Molecular Oncology, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Hideaki OdaDepartment of Pathology, Tokyo Women's Medical University, Tokyo, Japan.
Masashi SanadaDepartment of Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Seishi OgawaDepartment of Pathology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kohichiro TsujiDivision of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yasuhiro EbiharaDivision of Cellular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Linda WolffLaboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Zen-Ichiro HondaHealth Service Center, Ochanomizu University, Tokyo, Japan; and.
Toshio SudaCancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore.
Toshiya InabaDepartment of Molecular Oncology, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Hiroaki HondaDepartment of Disease Model, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Hiroshima University · JPKyoto University · JPThe University of Tokyo · JPKindai University · JPNational Center for Global Health and Medicine · JPNational Institutes of Health · USNational University Cancer Institute, Singapore · SGOchanomizu University · JPTokyo Women's Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic myelomonocytic leukemia (CMML) is a hematological malignancy characterized by uncontrolled proliferation of dysplastic myelomonocytes and frequent progression to acute myeloid leukemia (AML). We identified mutations in the

Indexed as

Cell CycleHematopoietic Stem CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMutation, MissenseMyelopoiesisProto-Oncogene Proteins c-cblUp-RegulationAmino Acid SubstitutionAnimalsGene Expression Regulation, EnzymologicLeukemia, Myeloid, AcuteMiceMice, TransgenicMonocytesMonomeric GTP-Binding ProteinsPhosphatidylinositol 3-KinasesCbl protein, mouseGem protein, mouseMonomeric GTP-Binding ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-cbl

Identifiers

PMID28209720
PMCPMC5391621
OpenAlexW2588494160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.