Evidence map›Paper›PMID 28209632›Full record

ArticleRNA (New York, N.Y.)2017

High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection.

Alper Celik, Richard Baker, Feng He, Allan Jacobson

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 127 citations in OpenAlex.

  1. Article
  2. Genome-wide mapping of DCP2-dependent 5' cap footprints inNAR genomics and bioinformatics · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. New reporters for monitoring cellular NMD.RNA (New York, N.Y.) · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alper CelikDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Richard BakerDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Feng HeDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Allan JacobsonDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
University of Massachusetts Chan Medical School · US

Funding

MESSENGER RNA METABOLISM IN YEASTR01GM027757 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JACOBSON, ALLAN S · 1985 to 2016
$3.8M
Genetic nonsense and its consequencesR35GM122468 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JACOBSON, ALLAN S · 2017 to 2021
$2.7M
NIGMS NIH HHS R01 GM027757NIGMS NIH HHS R35 GM122468
6 · The paper itself

Abstract

Nonsense-mediated mRNA decay (NMD) plays an important role in eukaryotic gene expression, yet the scope and the defining features of NMD-targeted transcripts remain elusive. To address these issues, we reevaluated the genome-wide expression of annotated transcripts in yeast cells harboring deletions of the

Indexed as

Gene Expression Regulation, FungalNonsense Mediated mRNA DecayAdaptor Proteins, Signal TransducingCodonExoribonucleasesGene DeletionIntronsProtein BiosynthesisRNA-Binding ProteinsRNA, FungalRNA HelicasesRNA PrecursorsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscriptomeAdaptor Proteins, Signal TransducingCodonExoribonucleasesNAM7 protein, S cerevisiaeNMD2 protein, S cerevisiaeRNA-Binding ProteinsRNA, FungalRNA HelicasesRNA PrecursorsSaccharomyces cerevisiae ProteinsUPF3 protein, S cerevisiaecodon optimalityNMD substratestranslational fidelity and efficiency

Identifiers

PMID28209632
PMCPMC5393182
OpenAlexW2587817388

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.