Evidence map›Paper›PMID 28209599›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic

Megha Singhal, Christopher Manzella, Vinay Soni, Waddah A Alrefai, Seema Saksena, Gail A Hecht, Pradeep K Dudeja, Ravinder K Gill

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Post-translational modifications of transporters.Pharmacology & therapeutics · 2018
    Review
  10. Article
  11. Review
  12. Pathophysiology of EnteropathogenicNewborn (Clarksville, Md.)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Megha SinghalDivision of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Christopher ManzellaDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois; and.
Vinay SoniDivision of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Waddah A AlrefaiDivision of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Seema SaksenaDivision of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Gail A HechtDivision of Gastroenterology and Nutrition, Departments of Medicine, Microbiology/Immunology, Loyola University Chicago, Chicago, Illinois.
Pradeep K DudejaDivision of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois.
Ravinder K GillDivision of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, Illinois; rgill@uic.edu.
University of Illinois Chicago · USJesse Brown VA Medical Center · USLoyola University Chicago · US

Funding

Intestinal 5-HT Transporter: A novel therapeutic target for GI disordersR01DK098170 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GILL, RAVINDER K · 2014 to 2022
$3.0M
Probiotics:Potential Therapeutic Roles in DiarrheaR01DK081858 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DUDEJA, PRADEEP K · 2008 to 2017
$2.5M
Regulation of Intestinal Bile Acid TransportR01DK071596 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALREFAI, WADDAH A. · 2005 to 2014
$2.3M
Mechanisms of Enteropathogenic E. coli Effects on Polarity and Tight JunctionsR01DK097043 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HECHT, GAIL A · 2012 to 2016
$1.6M
Gut-liver crosstalk in bile-acid induced diarrheaR01DK109709 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALREFAI, WADDAH A. · 2016 to 2019
$1.1M
Regulation of Intestinal Sodium Absorption in Health and DiseaseI01BX002867 · VA · JESSE BROWN VA MEDICAL CENTER · PI Seema Saksena · 2016 to 2026
–
Mechanisms of Cytoskeletal Regulation of Tight Junction Homeostasis and RepairI01BX002687 · VA · EDWARD HINES JR VA HOSPITAL · PI HECHT, GAIL A · 2016 to 2019
–
Mechanisms of Regulation of Intestinal Cl Absorption in IBD Associated DiarrheaI01BX002011 · VA · JESSE BROWN VA MEDICAL CENTER · PI DUDEJA, PRADEEP K · 2013 to 2024
–
BLRD VA I01 BX000152BLRD VA I01 BX002011BLRD VA I01 BX002687BLRD VA I01 BX002867BLRD VA IK6 BX005243NIDDK NIH HHS R01 DK071596NIDDK NIH HHS R01 DK081858NIDDK NIH HHS R01 DK097043NIDDK NIH HHS R01 DK098170NIDDK NIH HHS R01 DK109709
6 · The paper itself

Abstract

Enteropathogenic

Indexed as

Caco-2 CellsEnterocytesEnteropathogenic Escherichia coliEscherichia coliHumansProtein Tyrosine Phosphatase, Non-Receptor Type 11Serotonin Plasma Membrane Transport ProteinsProtein Tyrosine Phosphatase, Non-Receptor Type 11Serotonin Plasma Membrane Transport Proteins5-HTCaco-2diarrheaenteric infectionSHP2

Identifiers

PMID28209599
PMCPMC5451565
OpenAlexW2589016156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.