ArticleRedox biology2017
Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia.
Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury.Scientific reports · 2026Article
- Hypoxanthine-early biomarker of outcomes in an ovine model of neonatal hypoxic ischemic encephalopathy.Pediatric research · 2026Article
- Searching molecular biomarkers correlating with BSID-III at 24 months in infants with neonatal hypoxic-ischemic encephalopathy.European journal of pediatrics · 2024Article
- Dried Blood Spot Metabolome Features of Ischemic-Hypoxic Encephalopathy: A Neonatal Rat Model.International journal of molecular sciences · 2024Article
- Metabolite Biomarkers for Early Ischemic-Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model.International journal of molecular sciences · 2024Article
- Identification of Metabolomic Signatures for Ischemic Hypoxic Encephalopathy Using a Neonatal Rat Model.Children (Basel, Switzerland) · 2023Article
- Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model.Scientific reports · 2021Article
- Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides.Frontiers in molecular neuroscience · 2021Article
- Blood Plasma Metabolic Profile of Newborns with Hypoxic-Ischaemic Encephalopathy by GC-MS.BioMed research international · 2021Article
- Exploring Perinatal Asphyxia by Metabolomics.Metabolites · 2020Review
- Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes.Metabolites · 2020Article
- AMetabolomics : Official journal of the Metabolomic Society · 2019Article
- Oxygen therapy of the newborn from molecular understanding to clinical practice.Pediatric research · 2019Review
- Multiple-Omics Techniques Reveal the Role of Glycerophospholipid Metabolic Pathway in the Response ofFrontiers in microbiology · 2019Article
- Oxidative Stress in the Newborn Period: Useful Biomarkers in the Clinical Setting.Antioxidants (Basel, Switzerland) · 2018Review
- Blood biomarkers for evaluation of perinatal encephalopathy: state of the art.Current opinion in pediatrics · 2018Review
- Metabolomics profiling reveals different patterns in an animal model of asphyxial and dysrhythmic cardiac arrest.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxic-ischemic encephalopathy (HIE) secondary to perinatal asphyxia is a leading cause of mortality and acquired long-term neurologic co-morbidities in the neonate. The most successful intervention for the treatment of moderate to severe HIE is moderate whole body hypothermia initiated within 6h from birth. The objective and prompt identification of infants who are at risk of developing moderate to severe HIE in the critical first hours still remains a challenge. This work proposes a metabolite score calculated based on the relative intensities of three metabolites (choline, 6,8-dihydroxypurine and hypoxanthine) that showed maximum correlation with hypoxia time in a consolidated piglet model for neonatal hypoxia-ischemia. The metabolite score's performance as a biomarker for perinatal hypoxia and its usefulness for clinical grading and decision making have been assessed and compared to the performance of lactate which is currently considered the gold standard. For plasma samples withdrawn before and directly after a hypoxic insult, the metabolite score performed similar to lactate. However, it provided an enhanced predictive capacity at 2h after resuscitation. The present study evidences the usefulness of the metabolite score for improving the early assessment of the severity of the hypoxic insult based on serial determinations in a minimally invasive biofluid. The applicability of the metabolite score for clinical diagnosis and patient stratification for hypothermia treatment has to be confirmed in multicenter trials involving newborns suffering from HIE.
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