Evidence map›Paper›PMID 28209450›Full record

Trial reportChinese journal of traumatology = Zhonghua chuang shang za zhi2017

The effect of tranexamic acid in traumatic brain injury: A randomized controlled trial.

Abolfazl Jokar, Koorosh Ahmadi, Tayyebeh Salehi, Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar

Open access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 9 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 9 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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  3. Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024
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  10. Benefits of the tranexamic acid in head trauma with no extracranial bleeding: a prospective follow-up of 180 patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Abolfazl JokarDepartment of Emergency Medicine, Arak University of Medical Science, Arak, Iran.
Koorosh AhmadiDepartment of Emergency Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Tayyebeh SalehiDepartment of Emergency Medicine, Arak University of Medical Science, Arak, Iran.
Mahdi Sharif-AlhoseiniSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Vafa Rahimi-MovagharSina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: v_rahimi@sina.tums.ac.ir.
Arak University · IRJahrom University of Medical Sciences · IRShariati Hospital · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTraumatic brain injury (TBI) is a leading cause of death and disability. Intracranial hemorrhage (ICH) secondary to TBI is associated with a high risk of coagulopathy which leads to increasing risk of hemorrhage growth and higher mortality rate. Therefore, antifibrinolytic agents such as tranexamic acid (TA) might reduce traumatic ICH. The aim of the present study was to investigate the extent of ICH growth after TA administration in TBI patients.

methodsThis single-blind randomized controlled trial was conducted on patients with traumatic ICH (with less than 30 ml) referring to the emergency department of Vali-Asr Hospital, Arak, Iran in 2014. Patients, based on the inclusion and exclusion criteria, were divided into intervention and control groups (40 patients each). All patients received a conservative treatment for ICH, as well as either intravenous TA or placebo. The extent of ICH growth as the primary outcome was measured by brain CT scan after 48 h.

resultsAlthough brain CT scan showed a significant increase in hemorrhage volume in both groups after 48 h, it was significantly less in the TA group than in the control group (p = 0.04). The mean total hemorrhage expansion was (1.7 ± 9.7) ml and (4.3 ± 12.9) ml in TA and placebo groups, respectively (p < 0.001).

conclusionIt has been established that TA, as an effective hospital-based treatment for acute TBI, could reduce ICH growth. Larger studies are needed to compare the effectiveness of different doses.

Indexed as

AdultAntifibrinolytic AgentsBrain Injuries, TraumaticCerebral Hemorrhage, TraumaticFemaleHumansMaleMiddle AgedSingle-Blind MethodTomography, X-Ray ComputedTranexamic AcidAntifibrinolytic AgentsTranexamic AcidIntracranial hemorrhageTranexamic acidTraumaticTraumatic brain injuries

Identifiers

PMID28209450
PMCPMC5343096
OpenAlexW2579265858

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.