ArticleChinese journal of traumatology = Zhonghua chuang shang za zhi2017
Topical aqueous extract of Ephedra alata can improve wound healing in an animal model.
Article in Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Exploring the potential of aFrontiers in chemistry · 2024Article
- Phytochemical Screening, Antioxidant Potential, and LC-ESI-MS Profiling of Ephedra alata and Ephedra altissima Seeds Naturally Growing in Tunisia.Applied biochemistry and biotechnology · 2023Article
- The Potential of Medicinal Plants and Natural Products in the Treatment of Burns and Sunburn-A Review.Pharmaceutics · 2023Review
- Article
- Article
- Control ofSaudi journal of biological sciences · 2022Article
- Recent Advances in Experimental Burn Models.Biology · 2021Review
- A Review of theMolecules (Basel, Switzerland) · 2020Review
- The study of formulated Zoush ointment against wound infection and gene expression of virulence factors Pseudomonas aeruginosa.BMC complementary and alternative medicine · 2018Article
- Enhancement of wound healing by single-wall/multi-wall carbon nanotubes complexed with chitosan.International journal of nanomedicine · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEphedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing.
methodsAn aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E. alata was prepared and its wound and burn healing activities were tested in-vivo using an animal model for deep wound and full thickness skin burn. The effect was compared against a placebo ointment. Skin biopsies were evaluated by a blinded clinical histopathologist, in addition to digital analysis.
resultsPhytochemical analysis demonstrated the presence of the major classes of phytochemical compounds in the prepared extract including flavonoids, alkaloids, phytosteroids, phenolic compounds, volatile oils and tannins. As compared to placebo ointment, E. alata ointment significantly improved the healing of the wound ulcers, whereas it showed no advantage on the quality of the healing of burn ulcers.
conclusionE. alata extract is rich in phytochemical compounds and can improve wound healing when applied topically.
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