ReviewBrazilian journal of otorhinolaryngology
Proliferative verrucous leukoplakia: diagnosis, management and current advances.
Review in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Oxidative stress and antioxidant markers in oral leukoplakia: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Malignant transformation of proliferative Verrucous Leukoplakia-systematic review & meta-analysis.BMC oral health · 2025Pooled it
- Proliferative Verrucous Leukoplakia: An Expert Consensus Guideline for Standardized Assessment and Reporting.Head and neck pathology · 2021Guideline
- Management of Surgical Margins in the Excision of Oral Leukoplakia: A Scoping Review.Oral diseases · 2026Article
- The progression of proliferative verrucous leukoplakia can be detected through elevated levels of salivary matrix metalloproteinases.BMC oral health · 2026Article
- Proliferative verrucous leukoplakia management requires x-ray surveillance. A retrospective study of 78 cases.Clinical oral investigations · 2026Article
- Contemporary Classification and Diagnostic Pathways for Common Gingival and Alveolar Ridge Lesions.International journal of dentistry · 2026Review
- Laser Therapy Versus Conventional Treatments in Oral Leukoplakia: A Systematic Review of Efficacy, Recurrence, and Postoperative Outcomes.International journal of dentistry · 2026Review
- FAP promotes progression of oral leukoplakia via activation of PI3K/AKT pathway by interacting with ITGB1.Translational oncology · 2025Article
- Proliferative verrucous leukoplakia is associated with aggressive periodontal pathogens: a comparative study with oral lichen planus and chronic periodontitis cases.Clinical oral investigations · 2025Article
- A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023.International dental journal · 2025Article
- Common white lesions of the oral cavity: Review of clinical presentations and management.Canadian family physician Medecin de famille canadien · 2025Review
- Recent knowledge on squamous cell carcinoma of the oral cavity: Contributing factors, underlying molecular pathways, and current attitudes in the therapeutic approaches.International journal of molecular and cellular medicine · 2025Review
- Proliferative verrucous leukoplakia: a case report of multiple metachronous oral verrucous carcinoma.BMJ case reports · 2023Article
- Oral verrucous carcinoma: a diagnostic and therapeutic challenge.Radiology and oncology · 2023Article
- Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer.Frontiers in pharmacology · 2022Review
- Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies.Cancers · 2021Review
- Article
- Malignant transformation of oral leukoplakia: a multicentric retrospective study in Brazilian population.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Immune expression profile identification in a group of proliferative verrucous leukoplakia patients: a pre-cancer niche for oral squamous cell carcinoma development.Clinical oral investigations · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionProliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.
objectiveTo analyze the studies about Proliferative verrucous leukoplakia and develop a concise update.
methodsA Pubmed search identifying studies (laboratory research, case series and reviews of literature) that examined patients with Proliferative verrucous leukoplakia was realized.
resultsThere are not enough studies about Proliferative verrucous leukoplakia in the literature. The few found studies not present a consensus about its etiology and diagnosis criteria. Although several treatment strategies have been proposed, most of them still show a high recurrence rate.
conclusionMore research about Proliferative verrucous leukoplakia is necessary to understand and treat this disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.