Evidence map›Paper›PMID 28209095›Full record

ArticleInternational journal of occupational and environmental health2017

Leptospira seropositivity as a risk factor for Mesoamerican Nephropathy.

Alejandro Riefkohl, Oriana Ramírez-Rubio, Rebecca L Laws, Michael D McClean, Daniel E Weiner, James S Kaufman, Renee L Galloway, Sean V Shadomy, Marta Guerra, Juan José Amador and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of occupational and environmental health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Review
  9. Kidney Injury Biomarkers in Leptospirosis.Revista da Sociedade Brasileira de Medicina Tropical · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Kidney biomarkers in tropical infections: an update.Pathogens and global health · 2020
    Review
  15. Article
  16. Article
  17. Chronic kidney disease of non-traditional origin in Mesoamerica: a disease primarily driven by occupational heat stress.Revista panamericana de salud publica = Pan American journal of public health · 2020
    Article
  18. Review
  19. Article
  20. Let's take the heat out of the CKDu debate: more evidence is needed.Occupational and environmental medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Alejandro Riefkohla Department of Epidemiology , Boston University School of Public Health , Boston , MA , USA.ORCID 0000-0002-1948-9219
Oriana Ramírez-Rubioa Department of Epidemiology , Boston University School of Public Health , Boston , MA , USA.
Rebecca L Lawsc Department of Environmental Health , Boston University School of Public Health , Boston , MA , USA.ORCID 0000-0001-8249-5999
Michael D McCleanc Department of Environmental Health , Boston University School of Public Health , Boston , MA , USA.
Daniel E Weinerd Division of Nephrology, Department of Medicine , Tufts Medical Center and Tufts University School of Medicine , Boston , MA , USA.ORCID 0000-0002-8775-394X
James S Kaufmane Research Service, VA New York Harbor Healthcare System and New York University School of Medicine , New York , NY , USA.ORCID 0000-0002-6778-4167
Renee L Gallowayf Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens & Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta , GA , USA.
Sean V Shadomyf Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens & Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta , GA , USA.ORCID 0000-0001-7446-5263
Marta Guerraf Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens & Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention , Atlanta , GA , USA.
Juan José Amadora Department of Epidemiology , Boston University School of Public Health , Boston , MA , USA.
José Marcel Sáncheza Department of Epidemiology , Boston University School of Public Health , Boston , MA , USA.
Damaris López-Pilartea Department of Epidemiology , Boston University School of Public Health , Boston , MA , USA.
Chirag R Parikhg Section of Nephrology, Department of Medicine , Yale University , New Haven , CT , USA.
Jessica H Leiblerc Department of Environmental Health , Boston University School of Public Health , Boston , MA , USA.
Daniel R Brooksa Department of Epidemiology , Boston University School of Public Health , Boston , MA , USA.
Boston University · USCenters for Disease Control and Prevention · USTufts University · USVA NY Harbor Healthcare System · USYale University · US

Funding

Environmental Epidemiology in Community SettingsT32ES014562 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Birgit Gunhild Claus Henn · 2006 to 2026
$7.7M
NIEHS NIH HHS T32 ES014562
6 · The paper itself

Abstract

backgroundLeptospirosis is postulated as a possible cause of Mesoamerican Nephropathy (MeN) in Central American workers.

objectivesInvestigate job-specific Leptospira seroprevalence and its association with kidney disease biomarkers.

methodsIn 282 sugarcane workers, 47 sugarcane applicants and 160 workers in other industries, we measured anti-leptospiral antibodies, serum creatinine, and urinary injury biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and N-acetyl-D-glucosaminidase (NAG).

resultsLeptospira seroprevalence differed among job categories and was highest among sugarcane cutters (59%). Seropositive sugarcane workers had higher NGAL concentrations (relative mean: 1.28; 95% CI: 0.94-1.75) compared to those who were seronegative, with similar findings among field and non-field workers.

conclusionsLeptospira seroprevalence varied by job category. There was some indication that seropositivity was associated with elevated biomarker levels, but results were inconsistent. Additional studies may help establish whether Leptospira infection plays any role in MeN among Central American workers.

Indexed as

LeptospirosisRenal Insufficiency, ChronicAdultAntibodies, BacterialBiomarkersCreatinineFarmersFemaleHumansInterleukin-18LeptospiraLipocalin-2MaleMiddle AgedNicaraguaProspective StudiesAntibodies, BacterialBiomarkersCreatinineInterleukin-18LCN2 protein, humanLipocalin-2Chronic kidney disease (CKD)Chronic kidney disease of nontraditional etiology (CKDnt)IeptospirosisInterleukin-18 (IL-18)LeptospiraMesoamerican Nephropathy (MeN)N-acetyl-D- glucosaminidase (NAG)Neutrophil gelatinase-associated lipocalin (NGAL)

Identifiers

PMID28209095
PMCPMC6060841
OpenAlexW2587995001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.