ArticleJournal of clinical and diagnostic research : JCDR2016
Evaluation of Association of Hyperuricaemia with Metabolic Syndrome and Insulin Resistance.
Article in Journal of clinical and diagnostic research : JCDR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Hyperuricemia and Its Associated Factors Among Adult Staff Members of the Ethiopian Public Health Institute, Ethiopia.International journal of general medicine · 2021Article
- Insulin resistance-related differences in the relationship between left ventricular hypertrophy and cardiorespiratory fitness in hypertensive Black sub-Saharan Africans.American journal of cardiovascular disease · 2021Article
- The association between serum uric acid and features of metabolic disturbances in young adults.Archives of medical science : AMS · 2021Article
- Lumbar epidural lipomatosis is associated with visceral fat and metabolic disorders.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Article
- Safety and effectiveness of low-protein diet supplemented with ketoacids in diabetic patients with chronic kidney disease.BMC nephrology · 2018Observational
- Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy.Oncotarget · 2017Article
- Hyperuricemia in type 2 diabetic model KK-ABMC research notes · 2017Article
- Influencing factors of glycemic variability in hospitalized type 2 diabetes patients with insulin therapy: A Strobe-compliant article.Medicine · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe prevalence of Metabolic Syndrome (MetS) ranges from <10% to as much as 84% depending on region and composition of the population studied. The MetS is a growing public health problem in the world.
aimTo evaluate association of hyperuricaemia with components of MetS and insulin resistance. MATERIALS AND
methodsSixty patients with MetS were conveniently recruited. MetS was defined as per Adult Treatment Panel III (ATP III) guidelines. For the purpose of analysis study participants were grouped into, group-I (controls - normal serum uric acid levels) and group-II (cases - hyperuricaemia). Hyperuricaemia was defined with cut-off >6.8mg/dl in both men and women. Associated work up for MetS and insulin resistance like fasting blood sugar, fasting lipid profile, fasting insulin, serum uric acid was done. Blood pressure and anthropometric measurements including weight, height and waist circumferences were measured and BMI was calculated. HOMA IR method was used to measure the degree of insulin resistance. Logistic regression analysis was used to evaluate association of hyperuricaemia with MetS and insulin resistance. Receiver Operating Curve (ROC) was plotted to find out optimum cut-off value for insulin resistance.
resultsA significant increase in systolic blood pressure (p < 0.001) and triglyceride levels (p=0.027) were observed in hyperuricaemia subjects when compared to controls. After adjusting for potential confounders, Insulin resistance (HOMA IR >3.4) was independently associated with hyperuricaemia (OR=5.79, 95% CI=1.6- 20.69, p=0.007).
conclusionInsulin resistance beyond a threshold is independently associated with hyperuricaemia in subjects with MetS.
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