Evidence map›Paper›PMID 28208802›Full record

ArticleJournal of clinical medicine2017

The Effect of Mitochondrial Supplements on Mitochondrial Activity in Children with Autism Spectrum Disorder.

Leanna M Delhey, Ekim Nur Kilinc, Li Yin, John C Slattery, Marie L Tippett, Shannon Rose, Sirish C Bennuri, Stephen G Kahler, Shirish Damle, Agustin Legido and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03835117 (Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum Disorder), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03835117 phase2completednot on this mapstarted 2020, after this paper: background citation

Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum Disorder (ASD)

TypeinterventionalSponsorRossignol Medical CenterRan2020 to 2022Enrolled16ConditionsAutism Spectrum DisorderArmsWide-spectrum nutritional supplement, Placebo
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Leanna M DelheyArkansas Children's Research Institute, Little Rock, AR 72202, USA. lmdelhey@uams.edu.
Ekim Nur KilincArkansas Children's Research Institute, Little Rock, AR 72202, USA. ekimkilinc@gmail.com.
Li YinChild and Adolescent Department, Mental Health Centre, West China Hospital of Sichuan University, Chengdu 610041, China. dr.yinli@hotmail.com.
John C SlatteryArkansas Children's Research Institute, Little Rock, AR 72202, USA. jcslattery@uams.edu.
Marie L TippettArkansas Children's Research Institute, Little Rock, AR 72202, USA. mltippett@uams.edu.
Shannon RoseArkansas Children's Research Institute, Little Rock, AR 72202, USA. srose@uams.edu.
Sirish C BennuriArkansas Children's Research Institute, Little Rock, AR 72202, USA. scbennutri@uams.edu.
Stephen G KahlerArkansas Children's Research Institute, Little Rock, AR 72202, USA. kahlerstepheng@uams.edu.
Shirish DamleDepartment of Pediatrics, Drexel University College of Medicine, Neurology Section, St. Christopher's Hospital for Children, Philadelphia, PA 19134, USA. shirish.damle@drexelmed.edu.
Agustin LegidoDepartment of Pediatrics, Drexel University College of Medicine, Neurology Section, St. Christopher's Hospital for Children, Philadelphia, PA 19134, USA. agustin.legido@drexelmed.edu.
Michael J GoldenthalDepartment of Pediatrics, Drexel University College of Medicine, Neurology Section, St. Christopher's Hospital for Children, Philadelphia, PA 19134, USA. michael.goldenthal@drexelmed.edu.
Richard E FryeArkansas Children's Research Institute, Little Rock, AR 72202, USA. refrye@uams.edu.
Arkansas Children's Hospital · USDrexel University · USUniversity of Arkansas for Medical Sciences · USWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment for mitochondrial dysfunction is typically guided by expert opinion with a paucity of empirical evidence of the effect of treatment on mitochondrial activity. We examined citrate synthase and Complex I and IV activities using a validated buccal swab method in 127 children with autism spectrum disorder with and without mitochondrial disease, a portion of which were on common mitochondrial supplements. Mixed-model linear regression determined whether specific supplements altered the absolute mitochondrial activity as well as the relationship between the activities of mitochondrial components. Complex I activity was increased by fatty acid and folate supplementation, but folate only effected those with mitochondrial disease. Citrate synthase activity was increased by antioxidant supplementation but only for the mitochondrial disease subgroup. The relationship between Complex I and IV was modulated by folate while the relationship between Complex I and Citrate Synthase was modulated by both folate and B12. This study provides empirical support for common mitochondrial treatments and demonstrates that the relationship between activities of mitochondrial components might be a marker to follow in addition to absolute activities. Measurements of mitochondrial activity that can be practically repeated over time may be very useful to monitor the biochemical effects of treatments.

Indexed as

antioxidantsautism spectrum disorderB12Complex IComplex IVelectron transport chainfatty acidsfolatemitochondrial diseasemitochondrial dysfunction

Identifiers

PMID28208802
PMCPMC5332922
OpenAlexW2588668970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.