ReviewInternational journal of molecular sciences2017
The Interplay between Inflammation, Coagulation and Endothelial Injury in the Early Phase of Acute Pancreatitis: Clinical Implications.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
95 citing papers in PubMed, 5 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Association of systemic immune-inflammation index with type 2 diabetes mellitus and its prognostic significance: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- American College of Gastroenterology Guidelines: Management of Acute Pancreatitis.The American journal of gastroenterology · 2024Guideline
- Value of soluble fms-like tyrosine kinase 1 for predicting acute pancreatitis severity: a systematic review and meta-analysis.Revista da Associacao Medica Brasileira (1992) · 2024Pooled it
- Accuracy of angiopoietin-2 for predicting organ failure in patients with acute pancreatitis: a systematic review and meta-analysis.The Journal of international medical research · 2021Pooled it
- Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox.Science advances · 2021Pooled it
- Prognostic value of admission D-dimer in acute pancreatitis: association with disease severity and clinical outcomes in a retrospective cohort study.BMC gastroenterology · 2026Article
- Evaluation of the Admission Neutrophil Percentage-to-Albumin Ratio for Predicting the Severity of Acute Pancreatitis.Biomedicines · 2026Article
- An interpretable XGboost algorithm for predicting 30-day mortality in acute pancreatitis using routine biomarkers.BMC medical research methodology · 2026Article
- Article
- Mapping the vascular complications of acute pancreatitis: focus on splanchnic vein thrombosis.BMC gastroenterology · 2026Article
- Dynamic Assessment of Modified EASIX (m-EASIX) at 48 Hours Predicts Adverse Outcomes in Acute Pancreatitis: A Propensity Score-Matched Study.Medicina (Kaunas, Lithuania) · 2026Article
- Prognostic analysis of acute pancreatitis due to different etiologies and establishment and validation of an early prediction model.Lipids in health and disease · 2026Article
- Molecular Mechanisms and Therapeutic Potential of Baicalein in Acute Pancreatitis: A Comprehensive Review.Biomolecules · 2026Review
- Nanotherapy for Pancreatitis: From Single-Cell Targeting Toward Multicellular-Coordinated Regulation.International journal of nanomedicine · 2026Review
- Comparative associative and discriminative value of inflammatory, coagulation, hypoxia-perfusion, and electrolyte-metabolic indices for early respiratory physiological decompensation in acute pancreatitis.Frontiers in physiology · 2026Article
- Molecular frontiers in hemodialysis: unraveling the role of membranes in gene expression, epigenetics, and inflammatory pathways.International urology and nephrology · 2025Review
- Anticoagulation therapy for intra-abdominal hypertension in patients with acute pancreatitis.BMC gastroenterology · 2025Article
- Acute Necrotizing Pancreatitis-Advances and Challenges in Management for Optimal Clinical Outcomes.Medicina (Kaunas, Lithuania) · 2025Review
- Evaluation of Inflammatory Markers and Clinical Outcomes in Patients with Acute Pancreatitis: A Prospective Cohort Study.Journal of pharmacy & bioallied sciences · 2025Article
- Nonlinear association between estimated plasma volume status and acute kidney injury in acute pancreatitis patients.World journal of gastroenterology · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute pancreatitis (AP) is an inflammatory disease with varied severity, ranging from mild local inflammation to severe systemic involvement resulting in substantial mortality. Early pathologic events in AP, both local and systemic, are associated with vascular derangements, including endothelial activation and injury, dysregulation of vasomotor tone, increased vascular permeability, increased leukocyte migration to tissues, and activation of coagulation. The purpose of the review was to summarize current evidence regarding the interplay between inflammation, coagulation and endothelial dysfunction in the early phase of AP. Practical aspects were emphasized: (1) we summarized available data on diagnostic usefulness of the markers of endothelial dysfunction and activated coagulation in early prediction of severe AP; (2) we reviewed in detail the results of experimental studies and clinical trials targeting coagulation-inflammation interactions in severe AP. Among laboratory tests, d-dimer and angiopoietin-2 measurements seem the most useful in early prediction of severe AP. Although most clinical trials evaluating anticoagulants in treatment of severe AP did not show benefits, they also did not show significantly increased bleeding risk. Promising results of human trials were published for low molecular weight heparin treatment. Several anticoagulants that proved beneficial in animal experiments are thus worth testing in patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.