ArticleAnalytical chemistry2017
Ion Elevators and Escalators in Multilevel Structures for Lossless Ion Manipulations.
Article in Analytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Ion confinement and separation using asymmetric electrodynamic fields in structures for lossless ion manipulations.Rapid communications in mass spectrometry : RCM · 2024Article
- Altering Conformational States of Dynamic Ion Populations using Traveling Wave Structures for Lossless Ion Manipulations.Analytical chemistry · 2024Article
- A Miniature Multilevel Structures for Lossless Ion Manipulations Ion Mobility Spectrometer with Wide Mobility Range Separation Capabilities.Analytical chemistry · 2022Article
- Implementation of Ion Mobility Spectrometry-Based Separations in Structures for Lossless Ion Manipulations (SLIM).Methods in molecular biology (Clifton, N.J.) · 2022Article
- Resolving Power and Collision Cross Section Measurement Accuracy of a Prototype High-Resolution Ion Mobility Platform Incorporating Structures for Lossless Ion Manipulation.Journal of the American Society for Mass Spectrometry · 2021Article
- Ultra-High-Resolution Ion Mobility Separations Over Extended Path Lengths and Mobility Ranges Achieved using a Multilevel Structures for Lossless Ion Manipulations Module.Analytical chemistry · 2020Article
- A simulation study of the influence of the traveling wave patterns on ion mobility separations in structures for lossless ion manipulations.The Analyst · 2019Article
- Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses.Analytical and bioanalytical chemistry · 2019Article
- Opening new paths for biological applications of ion mobility - mass spectrometry using Structures for Lossless Ion Manipulations.Trends in analytical chemistry : TRAC · 2019Article
- ISiCLE: A Quantum Chemistry Pipeline for Establishing in Silico Collision Cross Section Libraries.Analytical chemistry · 2019Article
- Characterization of applied fields for ion mobility separations in traveling wave based structures for lossless ion manipulations (SLIM).International journal of mass spectrometry · 2018Article
- Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics.Metabolites · 2018Review
- New frontiers for mass spectrometry based upon structures for lossless ion manipulations.The Analyst · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We describe two approaches based upon ion "elevator" and "escalator" components that allow moving ions to different levels in structures for lossless ion manipulations (SLIM). Guided by ion motion simulations, we designed elevator and escalator components based upon ion current measurements providing essentially lossless transmission in multilevel designs. The ion elevator design allowed ions to efficiently bridge a 4 mm gap between levels. The component was integrated in a SLIM and coupled to a QTOF mass spectrometer using an ion funnel interface to evaluate the m/z range transmitted as compared to transmission within a level (e.g., in a linear section). The analysis of singly charged ions of m/z 600-2700 produced similar mass spectra for both elevator and straight (linear motion) components. In the ion escalator design, traveling waves (TW) were utilized to transport ions efficiently between two SLIM levels. Ion current measurements and ion mobility (IM) spectrometry analysis illustrated that ions can be transported between TW-SLIM levels with no significant loss of either ions or IM resolution. These developments provide a path for the development of multilevel designs providing, e.g., much longer IM path lengths, more compact designs, and the implementation of much more complex SLIM devices in which, e.g., different levels may operate at different temperatures or with different gases.
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Registered trials
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