ArticleBritish journal of cancer2017
Gestational diabetes mellitus may be associated with increased risk of breast cancer.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The association of pregnancy complications/risk factors with the development of cancer in women: an umbrella review.BMC medicine · 2026Pooled it
- Association between gestational diabetes mellitus and risk of breast cancer: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Genetic Evidence Links Gestational Diabetes Mellitus to Increased ER-Negative Breast Cancer Risk Through a Mendelian Randomization Analysis.International journal of endocrinology · 2026Article
- Gestational and postpartum maternal consequences of gestational diabetes mellitus.Frontiers in endocrinology · 2026Article
- The association between gestational diabetes mellitus and cancer in women: an updated systematic review and meta-analysis.Journal of diabetes and metabolic disorders · 2025Article
- Gestational Metabolic Risk: A Narrative Review of Pregnancy-Related Complications and of the Effectiveness of Dietary, Exercise and Lifestyle Interventions during Pregnancy on Reducing Gestational Weight Gain and Preventing Gestational Diabetes Mellitus.Journal of clinical medicine · 2024Review
- The Relationship Between Gestational Diabetes and the Risk of Cancer: A Systematic Review.Cureus · 2024Review
- Effectiveness of Lifestyle Interventions during Pregnancy on Preventing Gestational Diabetes Mellitus in High-Risk Women: A Systematic Review and Meta-Analyses of Published RCTs.Journal of clinical medicine · 2023Review
- Gestational diabetes and risk of breast cancer before age 55 years.International journal of epidemiology · 2022Article
- The Risk Factors, Incidence and Prognosis of Postpartum Breast Cancer: A Nationwide Study by the SMARTSHIP Group.Frontiers in oncology · 2022Article
- Developing the breast cancer risk prediction system using hybrid machine learning algorithms.Journal of education and health promotion · 2022Article
- Is Gestational Diabetes Mellitus a Risk Factor of Maternal Breast Cancer? A Systematic Review of the Literature.Biomedicines · 2021Review
- Gestational Diabetes and Risk of Breast Cancer in African American Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Heightened susceptibility: A review of how pregnancy and chemical exposures influence maternal health.Reproductive toxicology (Elmsford, N.Y.) · 2020Review
- Altered Genome-Wide DNA Methylation in Peripheral Blood of South African Women with Gestational Diabetes Mellitus.International journal of molecular sciences · 2019Article
- Endogenous SHBG levels correlate with that of glucose transporters in insulin resistance model cells.Molecular biology reports · 2019Article
- Incidence and relative risk for developing cancers in women with gestational diabetes mellitus: a nationwide cohort study in Taiwan.BMJ open · 2019Article
- Article
- Gestational diabetes, type II diabetes, and mammographic breast density in a U.S. racially diverse population screened for breast cancer.Cancer causes & control : CCC · 2018Article
- Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine.The EPMA journal · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough a positive association between type 2 diabetes and breast cancer has been reported, an association with gestational diabetes mellitus (GDM) is less clear.
methodsThe Sister Study enroled 50 884 women aged 35-74 years, from 2003 through 2009. Cox proportional hazards models were used to estimate breast cancer risk in relation to GDM.
resultsEver having GDM was not associated with breast cancer overall (hazards ratio (HR)=1.10, 95% confidence interval (CI)=0.88-1.36), but there was a suggestive association between ever having a GDM pregnancy and oestrogen receptor (ER) -negative breast cancer (HR=1.73, 95% CI=0.98-3.06). However, having 2 or more GDM pregnancies was associated with overall breast cancer risk 1.68 (95% CI=1.15-2.44) and with ER-positive breast cancer (HR=1.81, 95% CI=1.10-2.98), which was supported by sensitivity analyses. Results were similar when analyses were stratified by whether or not type 2 diabetes had developed after GDM.
conclusionsWomen with multiple GDM pregnancies had a higher incidence of breast cancer, suggesting that such women could benefit from increased surveillance for breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.