ArticlePsychiatry research. Neuroimaging2017
Altered olfactory processing and increased insula activity in patients with obsessive-compulsive disorder: An fMRI study.
Article in Psychiatry research. Neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder.Journal of autism and developmental disorders · 2020Pooled it
- Affective modulation of the associative-limbic subthalamic nucleus: deep brain stimulation in obsessive-compulsive disorder.Translational psychiatry · 2019Trial
- Reconsidering Ondansetron for Smoking Cessation: A Call for Renewed Investigation.Pharmacology research & perspectives · 2025Article
- Inflammation and olfactory loss are associated with at least 139 medical conditions.Frontiers in molecular neuroscience · 2024Article
- Pharmacological and Psychological Treatment Have Common and Specific Effects on Brain Activity in Obsessive-Compulsive Disorder.Depression and anxiety · 2024Article
- The Seeking Proxies for Internal States (SPIS) Model of OCD - A Comprehensive Review of Current Findings and Implications for Future Directions.Current neuropharmacology · 2024Review
- Olfactory Obsessions: A Study of Prevalence and Phenomenology in the Course of Obsessive-Compulsive Disorder.Journal of clinical medicine · 2023Article
- Relationships between interoceptive sensibility and resting-state functional connectivity of the insula in obsessive-compulsive disorder.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Pleasantness Recognition Induced by Different Odor Concentrations Using Olfactory Electroencephalogram Signals.Sensors (Basel, Switzerland) · 2022Article
- Anti-Disgust Cognitive Behavioral Therapy for Contamination-Based Obsessive Compulsive Disorder: A Randomized Controlled Clinical Trial.Journal of clinical medicine · 2022Article
- Obsessive-compulsive disorder-contamination fears, features, and treatment: novel smartphone therapies in light of global mental health and pandemics (COVID-19).CNS spectrums · 2022Review
- Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression.Frontiers in neuroscience · 2022Article
- Functional Brain Imaging and OCD.Current topics in behavioral neurosciences · 2021Review
- Odor sensitivity impairment: a behavioral marker of psychological distress?CNS spectrums · 2019Article
- Erroneously Disgusted: fMRI Study Supports Disgust-Related Neural Reuse in Obsessive-Compulsive Disorder (OCD).Frontiers in behavioral neuroscience · 2019Article
- Psychic euosmia and obsessive compulsive personality disorder.World journal of psychiatry · 2018Article
- Disgust in Anxiety and Obsessive-Compulsive Disorders: Recent Findings and Future Directions.Current psychiatry reports · 2018Review
- Decoding moral emotions in obsessive-compulsive disorder.NeuroImage. Clinical · 2018Article
- Preliminary evidence for differential olfactory and trigeminal processing in combat veterans with and without PTSD.NeuroImage. Clinical · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Obsessive-compulsive disorder (OCD) patients show increased insula activation to disgust-inducing images compared to healthy controls (HC). We explored whether this disgust reactivity was also present in the olfactory domain by conducting the first fMRI study of olfaction in OCD. Neural activation in response to pleasant and unpleasant odors (vs. unscented air) was investigated in 15 OCD and 15 HC participants using fMRI. OCD participants (vs. HC) had increased left anterior insula activation to unpleasant odors (vs. unscented air), which positively correlated with their disgust sensitivity and ratings of the unpleasantness and intensity of those odors. OCD participants (vs. HC) showed increased activation of caudate nucleus and left anterior and posterior insula to pleasant odors (vs. unscented air), which positively correlated with their OCD symptom severity, trait anxiety, frequency of feeling disgust, and odor intensity ratings. OCD participants had increased anterior insula activation to both pleasant and unpleasant odors, which correlated with their OCD symptoms, anxiety, disgust sensitivity, and frequency of feeling disgust. OCD patients might have a negative cognitive bias and experience all stimuli, regardless of valence, as being more unpleasant than healthy people. These findings further elucidate the neural underpinnings of OCD and may contribute to more effective treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.