Evidence map›Paper›PMID 28207989›Full record

ArticleInfluenza and other respiratory viruses2017

Predictors of influenza a molecular viral shedding in Hutterite communities.

Biao Wang, Margaret L Russell, Kevin Fonseca, David J D Earn, Gregory Horsman, Paul Van Caeseele, Khami Chokani, Mark Vooght, Lorne Babiuk, Stephen D Walter and 1 more

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Influenza A and B Viral Shedding in Adults Immunized With Live Attenuated Influenza Vaccine.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: ‎possible cohort effect following the 2009 influenza pandemic.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Biao WangDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Margaret L RussellDepartment of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Kevin FonsecaDepartment of Microbiology and Infectious Diseases and Provincial Laboratory for Public Health, University of Calgary, Calgary, AB, Canada.
David J D EarnDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
Gregory HorsmanSaskatchewan Disease Control Laboratory, Regina, SK, Canada.
Paul Van CaeseeleCadham Provincial Laboratory, Winnipeg, MB, Canada.
Khami ChokaniSaskatchewan Health, Prince Albert Parkland Health Region, Prince Albert, SK, Canada.
Mark VooghtSaskatchewan Health, Five Hills Health Region, Moose Jaw, SK, Canada.
Lorne BabiukUniversity of Alberta, Edmonton, AB, Canada.
Stephen D WalterDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
Mark LoebDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-2315-5390
McMaster University · CASaskatchewan Health · CAUniversity of Calgary · CAManitoba Beekeepers' Association · CASaskatchewan Disease Control Laboratory · CAUniversity of Alberta · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundPatterns of influenza molecular viral shedding following influenza infection have been well established; predictors of viral shedding however remain uncertain.

objectivesWe sought to determine factors associated with peak molecular viral load, duration of shedding, and viral area under the curve (AUC) in children and adult Hutterite colony members with laboratory-confirmed influenza.

methodsA cohort study was conducted in Hutterite colonies in Alberta, Canada. Flocked nasal swabs were collected during three influenza seasons (2007-2008 to 2009-2010) from both symptomatic and asymptomatic individuals infected with influenza. Samples were tested by real-time reverse-transcription polymerase chain reaction for influenza A and influenza B, and the viral load was determined for influenza A-positive samples.

resultsFor seasonal H1N1, younger age was associated with a larger AUC, female sex was associated with decreased peak viral load and reduced viral shedding duration, while the presence of comorbidity was associated with increased peak viral load. For H3N2, younger age was associated with increased peak viral load and increased AUC. For pandemic H1N1, younger age was associated with increased peak viral load and increased viral AUC, female sex was associated with reduced peak viral load, while inapparent infection was associated with reduced peak viral load, reduced viral shedding duration, and reduced viral AUC.

conclusionsPatterns of molecular viral shedding vary by age, sex, comorbidity, and the presence of symptoms. Predictor variables vary by influenza A subtype.

Indexed as

Virus SheddingAdolescentAdultAlbertaChildChild, PreschoolCohort StudiesFemaleHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMaleMiddle AgedOrthomyxoviridaeinfluenza viral sheddingpredictorsviral AUCviral loadviral shedding duration

Identifiers

PMID28207989
PMCPMC5410723
OpenAlexW2587999459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.