SynthesisWorldviews on evidence-based nursing2017
Understanding Ethical Issues of Research Participation From the Perspective of Participating Children and Adolescents: A Systematic Review.
Synthesis in Worldviews on evidence-based nursing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The Use of Waivers of Guardian Permission in the United States for Pediatric Digital Health Intervention Research Since 2020: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Missing assent: a global systematic review of ethical practices in HIV research with men who have sex with men (MSM) under 18.BMC medical ethics · 2026Pooled it
- A Systematic Review of Research and Governance in Child and Adolescent Mental Health in Africa.Tropical medicine & international health : TM & IH · 2025Pooled it
- Pooled it
- Antiemetic medications for preventing chemotherapy-induced nausea and vomiting in children: a systematic review and Bayesian network meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- A phase 2 pharmacokinetic and pharmacodynamic dose-finding study of oral NEPA for chemotherapy-induced nausea and vomiting in pediatric patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Trial
- Evaluating the use of multimedia information when recruiting adolescents to orthodontics research: A randomised controlled trial.Journal of orthodontics · 2021Trial
- Children's participation in assent to paediatric oncology research: experiences of children, siblings and parents.Trials · 2026Article
- Digital Health Literacy in Pediatric Rheumatic Disease: A Qualitative Study Using Interpretive Description.Children (Basel, Switzerland) · 2026Article
- Child and mother study satisfaction in a longitudinal study of children at-risk for type 1 diabetes.BMC pediatrics · 2026Observational
- Better Design, Better Engagement, Better Data: Adolescents' Insights for Improving Health Research.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Ethical reporting of consent and assent in paediatric oral health research in Malaysia: a scoping review.BMC medical ethics · 2026Article
- Ethical Reporting of Consent and Assent in Paediatric Oral Health Research in Malaysia: A Scoping Review.Research square · 2025Article
- What Constitutes High-Quality Paediatric Palliative Care? A Qualitative Exploration of the Perspectives of Children, Young People, and Parents.The patient · 2025Article
- Advancing youth co-design of ethical guidelines for AI-powered digital mental health tools.Nature. Mental health · 2025Article
- Community Stakeholders' Perspectives on Recruiting Young Adolescents (Age 10-14) in Sexual Health Research.Healthcare (Basel, Switzerland) · 2025Article
- Bioethics training needs assessment for HIV research in vulnerable populations: a survey of trainees at college of health sciences, Makerere university.BMC medical ethics · 2025Article
- Fueling Soccer Players: A Scoping Review and Audit of Literature Related to Soccer-Specific Guidelines for Carbohydrate Intake.Sports medicine (Auckland, N.Z.) · 2025Article
- Are Adolescents Sensitive About Sensitive Data? Exploring Student Concerns About Privacy, Confidentiality, and Data Use in Health Research.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundThe past 20 years have seen distinct shifts in the way the participation of children and adolescents in research is viewed. This has been emphasized by the growing pediatric research enterprise. Additional information on children's and adolescents' experiences during research participation is needed to better inform researchers on the ethical conduct of research with this vulnerable population.
aimsThe objective of this analysis was to examine ethical issues in research with children and adolescents from their perspective as participants, including: assent, parental consent, risk perception, impact of research participation, and incentives.
methodsThis systematic review was conducted per the Long, Godfrey, Randall, Brettle, and Grant framework by means of an iterative searching process. Using the key words "research ethics" and "child or pediatric or adolescent," PubMed, CINAHL, and EBSCOhost databases were searched to identify articles. Limitations placed on the searches were: English language, year of publication between 2003 and 2014, humans, abstract available, and age birth-18 years.
findingsTwenty-three empiric studies were identified and formed the sample. Included studies represented a diverse range of areas of research, methods, settings, sample demographics, authors, and journals. LINKING EVIDENCE TO ACTION: Even young children demonstrated the ability to understand essential elements of research, although there is variability in children's level of understanding. Trust was a significant contributing factor to children's and adolescents' participation in research, and also shaped their assessments of risk. Research participation was mainly beneficial for children and adolescents. Incentives were mainly viewed positively, although concerns of possible undue influence were expressed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.