ArticleLab on a chip2017
Pneumatic stimulation of C. elegans mechanoreceptor neurons in a microfluidic trap.
Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Mechanosensory encoding of surface mechanics optimizes locomotion.Nature communications · 2026Article
- Integrative functional optical imaging approaches: Optics, microfluidics, and machine learning for neuroscience in organoids and small-animal models.Biophysical journal · 2025Review
- Obstacles Regulate Membrane Tension Propagation to Enable Localized Mechanotransduction.bioRxiv : the preprint server for biology · 2025Article
- A Modular, Cost-Effective, and Pumpless Perfusion Assembly for the Long-Term Culture of Engineered Microvessels.Micromachines · 2025Article
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins.eLife · 2025Article
- Advanced Neural Functional Imaging inMicromachines · 2024Review
- C. elegans touch receptor neurons direct mechanosensory complex organization via repurposing conserved basal lamina proteins.Current biology : CB · 2024Article
- A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans.PLoS biology · 2024Article
- Automated dual olfactory device for studying head/tail chemosensation inAPL bioengineering · 2024Article
- Microfluidic approach to correlateLab on a chip · 2024Article
- Dynamic temperature control in microfluidics for in vivo imaging of cold-sensing in C. elegans.Biophysical journal · 2024Article
- A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing.Nature cell biology · 2023Article
- An expanded GCaMP reporter toolkit for functional imaging in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2023Article
- Neural engineering with photons as synaptic transmitters.Nature methods · 2023Article
- An expanded GCaMP reporter toolkit for functional imaging inbioRxiv : the preprint server for biology · 2023Article
- Axonal plasticity in response to active forces generated through magnetic nano-pulling.Cell reports · 2023Article
- Microfluidic-AssistedCyborg and bionic systems (Washington, D.C.) · 2023Article
- Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices.BME frontiers · 2023Review
- Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy.Communications biology · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
New tools for applying force to animals, tissues, and cells are critically needed in order to advance the field of mechanobiology, as few existing tools enable simultaneous imaging of tissue and cell deformation as well as cellular activity in live animals. Here, we introduce a novel microfluidic device that enables high-resolution optical imaging of cellular deformations and activity while applying precise mechanical stimuli to the surface of the worm's cuticle with a pneumatic pressure reservoir. To evaluate device performance, we compared analytical and numerical simulations conducted during the design process to empirical measurements made with fabricated devices. Leveraging the well-characterized touch receptor neurons (TRNs) with an optogenetic calcium indicator as a model mechanoreceptor neuron, we established that individual neurons can be stimulated and that the device can effectively deliver steps as well as more complex stimulus patterns. This microfluidic device is therefore a valuable platform for investigating the mechanobiology of living animals and their mechanosensitive neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.