Trial reportAnnals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists2017
Fear conditioning and extinction in pediatric obsessive-compulsive disorder.
Trial report in Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder.Translational psychiatry · 2021Trial
- Fear extinction learning as a predictor of response to cognitive behavioral therapy for pediatric obsessive compulsive disorder.Journal of anxiety disorders · 2019Trial
- Symptom Dimension Response in Children and Adolescents with Obsessive-Compulsive Disorder.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Are Fear Learning Processes Altered in Obsessive-Compulsive Disorder, Social Anxiety, and Specific Phobia? Insights From the Late Positive Potential, Fear-Potentiated Startle, and Ratings.Psychophysiology · 2026Article
- Using latent patient-centered fear extinction profiles to guide treatment in pediatric OCD.Psychiatry research · 2025Article
- Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats.Molecular neurobiology · 2023Article
- Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach.Translational psychiatry · 2023Article
- Internet-based cognitive behavioral therapy in children and adolescents with obsessive compulsive disorder: a feasibility study.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Alterations in fear extinction neural circuitry and fear-related behavior linked to trauma exposure in children.Behavioural brain research · 2021Article
- Effects of Treatment Setting on Outcomes of Flexibly-Dosed Intensive Cognitive Behavioral Therapy for Pediatric OCD: A Randomized Controlled Pilot Trial.Frontiers in psychiatry · 2021Article
- Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors.Behavioural brain research · 2021Article
- Examining Differences in Fear Learning in Patients With Obsessive-Compulsive Disorder With Pupillometry, Startle Electromyography and Skin Conductance Responses.Frontiers in psychiatry · 2021Article
- Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder.The American journal of psychiatry · 2021Review
- Developmental Considerations in Obsessive Compulsive Disorder: Comparing Pediatric and Adult-Onset Cases.Frontiers in psychiatry · 2021Review
- Effects of the COVID-19 Pandemic on Obsessive-Compulsive Symptoms Among University Students: Prospective Cohort Survey Study.Journal of medical Internet research · 2020Article
- The 'Threat of Scream' paradigm: a tool for studying sustained physiological and subjective anxiety.Scientific reports · 2020Article
- Article
- Pediatric OCD in the era of RDoC.Journal of obsessive-compulsive and related disorders · 2019Article
- Anger Rumination is not Uniquely Characteristic of Obsessive-Compulsive Disorder.Personality and individual differences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundFear acquisition and extinction are central constructs in the cognitive-behavioral model of obsessive-compulsive disorder (OCD), which underlies exposure-based cognitive-behavioral therapy. Youths with OCD may have impairments in fear acquisition and extinction that carry treatment implications.
methodsEighty youths (39 OCD, 41 healthy controls [HC]) completed clinical interviews, rating scales, and a differential conditioning task that included habituation, acquisition, and extinction phases. Skin conductance response (SCR) served as the primary dependent measure.
resultsDuring habituation, participants with OCD exhibited a stronger orienting SCR to initial stimuli relative to HC participants. During acquisition, differential fear conditioning was observed for both groups as evidenced by larger SCRs to the visual conditioned stimulus paired with an aversive unconditioned stimulus (CS+) compared with a CS-; OCD participants exhibited a larger SCR to the CS+ relative to HC participants. The absolute magnitude of the unconditioned fear response was significantly larger in participants with OCD, compared with HC participants. During extinction, OCD participants continued to exhibit a differential SCR to the CS+ and CS-, whereas HC participants exhibited diminished SCR to both stimuli.
conclusionsParticipants with OCD exhibit a different pattern of fear extinction relative to HC participants, suggestive of greater fear acquisition and impaired inhibitory learning.
Indexed as
Identifiers
28207912PMC5964984W2885723671What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.