ArticlePloS one2017
The Drosophila speciation factor HMR localizes to genomic insulator sites.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- ThemicroPublication biology · 2025Article
- Stonewall prevents expression of ectopic genes in the ovary and accumulates at insulator elements in D. melanogaster.PLoS genetics · 2022Article
- The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila.PLoS genetics · 2021Article
- A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation.Nucleic acids research · 2020Article
- Altered Localization of Hybrid Incompatibility Proteins in Drosophila.Molecular biology and evolution · 2019Article
- Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization.Nucleic acids research · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hybrid incompatibility between Drosophila melanogaster and D. simulans is caused by a lethal interaction of the proteins encoded by the Hmr and Lhr genes. In D. melanogaster the loss of HMR results in mitotic defects, an increase in transcription of transposable elements and a deregulation of heterochromatic genes. To better understand the molecular mechanisms that mediate HMR's function, we measured genome-wide localization of HMR in D. melanogaster tissue culture cells by chromatin immunoprecipitation. Interestingly, we find HMR localizing to genomic insulator sites that can be classified into two groups. One group belongs to gypsy insulators and another one borders HP1a bound regions at active genes. The transcription of the latter group genes is strongly affected in larvae and ovaries of Hmr mutant flies. Our data suggest a novel link between HMR and insulator proteins, a finding that implicates a potential role for genome organization in the formation of species.
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