ArticlePloS one2017
Hyaluronic acid synthesis is required for zebrafish tail fin regeneration.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Intracellular pH dynamics promotes zebrafish larval tail regeneration.bioRxiv : the preprint server for biology · 2026Article
- Article
- Disruption of the creb3l1 gene causes defects in caudal fin regeneration and patterning in zebrafish Danio rerio.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Molecular basis of retinal remodeling in a zebrafish model of retinitis pigmentosa.Cellular and molecular life sciences : CMLS · 2023Article
- Article
- The Expression and Function of lincRNA-154324 and the Adjoining Protein-Coding GeneInternational journal of molecular sciences · 2022Article
- Heterogeneous pdgfrb+ cells regulate coronary vessel development and revascularization during heart regeneration.Development (Cambridge, England) · 2022Article
- Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development.Cardiovascular research · 2022Article
- Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis.Cell · 2021Article
- The Role of Extracellular Matrix in Skin Wound Healing.Journal of clinical medicine · 2021Review
- HDAC Inhibitor Titration of Transcription and Axolotl Tail Regeneration.Frontiers in cell and developmental biology · 2021Article
- Balance Between Tooth Size and Tooth Number Is Controlled by Hyaluronan.Frontiers in physiology · 2020Article
- Regenerative Scar-Free Skin Wound Healing.Tissue engineering. Part B, Reviews · 2019Review
- Glycosaminoglycans compositional analysis of Urodele axolotl (Ambystoma mexicanum) and Porcine Retina.Glycoconjugate journal · 2019Article
- Understanding the Metabolic Profile of Macrophages During the Regenerative Process in Zebrafish.Frontiers in physiology · 2019Article
- Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury.Respiratory research · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Using genome-wide transcriptional profiling and whole-mount expression analyses of zebrafish larvae, we have identified hyaluronan synthase 3 (has3) as an upregulated gene during caudal fin regeneration. has3 expression is induced in the wound epithelium within hours after tail amputation, and its onset and maintenance requires fibroblast growth factor, phosphoinositide 3-kinase, and transforming growth factor-ß signaling. Inhibition of hyaluronic acid (HA) synthesis by the small molecule 4-methylumbelliferone (4-MU) impairs tail regeneration in zebrafish larvae by preventing injury-induced cell proliferation. In addition, 4-MU reduces the expression of genes associated with wound epithelium and blastema function. Treatment with glycogen synthase kinase 3 inhibitors rescues 4-MU-induced defects in cell proliferation and tail regeneration, while restoring a subset of wound epithelium and blastema markers. Our findings demonstrate a role for HA biosynthesis in zebrafish tail regeneration and delineate its epistatic relationships with other regenerative processes.
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Registered trials
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