ArticlePreventing chronic disease2017
Absence of Fluoride Varnish-Related Adverse Events in Caries Prevention Trials in Young Children, United States.
Article in Preventing chronic disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01129440 (Glass Ionomer Sealant and Fluoride Varnish Randomized Clinical Trial), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glass Ionomer Sealant and Fluoride Varnish Randomized Clinical Trial
Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Oral Health Promotion Among Students in Special Education Schools: Protocol for a Multicity Cluster Randomized Controlled Trial.JMIR research protocols · 2026Article
- Comparative Evaluation of Remineralization Efficacy of a Novel Proanthocyanidin Biovarnish with Fluoride Varnish on Primary Teeth: AnInternational journal of clinical pediatric dentistry · 2025Article
- The Efficacy of Remineralizing Materials on Artificial Enamel Lesions: An In Vitro Study.Medicina (Kaunas, Lithuania) · 2025Article
- Topical fluoride hesitancy and opposition are significantly and positively associated: A cross-sectional study.PloS one · 2025Article
- Effect of Fluoride Varnishes on Demineralization and Acid Resistance in Subsurface Demineralized Lesion Models.Journal of functional biomaterials · 2024Article
- Observational
- Article
- Minimally Invasive Therapies for the Management of Dental Caries-A Literature Review.Dentistry journal · 2021Review
- Child Fluoride Varnish Programs Implementation: A Consensus Workshop and Actions to Increase Scale-Up in Australia.Healthcare (Basel, Switzerland) · 2021Article
- Long-term exposure to low level of fluoride induces apoptosis via p53 pathway in lymphocytes of aluminum smelter workers.Environmental science and pollution research international · 2019Article
- Randomized Trial of Motivational Interviewing to Prevent Early Childhood Caries in Public Housing.JDR clinical and translational research · 2018Article
- Parent Refusal of Topical Fluoride for Their Children: Clinical Strategies and Future Research Priorities to Improve Evidence-Based Pediatric Dental Practice.Dental clinics of North America · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 1 country.
Funding
Abstract
introductionFluoride varnish is an effective prevention intervention for caries in young children. Its routine use in clinical care is supported by meta-analyses and recommended by clinical guidelines, including the US Preventive Services Task Force (B rating). This report is the first prospective systematic assessment of adverse events related to fluoride varnish treatment in young children.
methodsWe determined the incidence of adverse events related to fluoride varnish treatment in 3 clinical trials on the prevention of early childhood caries, conducted under the auspices of the Early Childhood Caries Collaborating Centers, an initiative sponsored by the National Institute of Dental and Craniofacial Research. Each trial incorporated use of fluoride varnish in its protocol and systematically queried all children's parents or legal guardians about the occurrence of acute adverse events after each fluoride varnish treatment.
resultsA total of 2,424 community-dwelling, dentate children aged 0 to 5 years were enrolled and followed for up to 3 years. These children received a cumulative total of 10,249 fluoride varnish treatments. On average, each child received 4.2 fluoride varnish treatments. We found zero fluoride varnish-related adverse events.
conclusionFluoride varnish was not associated with treatment-related adverse events in young children. Our findings support its safety as an effective prevention intervention for caries in young children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.