Evidence map›Paper›PMID 28207234›Full record

ArticleACS infectious diseases2017

Potassium Iodide Potentiates Broad-Spectrum Antimicrobial Photodynamic Inactivation Using Photofrin.

Liyi Huang, Grzegorz Szewczyk, Tadeusz Sarna, Michael R Hamblin

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 140 citations in OpenAlex.

  1. Photodynamic anti-biofilm PHEMA/Rose Bengal hydrogels enhanced by iodide: evidence for hydrogen peroxide and triiodide formation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
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  9. Generation of singlet oxygen inside living cells: correlation between phosphorescence decay lifetime, localization and outcome of photodynamic action.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

Liyi HuangDepartment of Infectious Diseases, First Affiliated Hospital, Guangxi Medical University , Nanning, China 530021.
Grzegorz SzewczykDepartment of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , 31-007 Krakow, Poland.
Tadeusz SarnaDepartment of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University , 31-007 Krakow, Poland.
Michael R HamblinWellman Center for Photomedicine, Massachusetts General Hospital , Boston, Massachusetts 02114, United States.ORCID 0000-0001-6431-4605
Harvard University · USJagiellonian University · PL

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

It is known that noncationic porphyrins such as Photofrin (PF) are effective in mediating antimicrobial photodynamic inactivation (aPDI) of Gram-positive bacteria or fungi. However, the aPDI activity of PF against Gram-negative bacteria is accepted to be extremely low. Here we report that the nontoxic inorganic salt potassium iodide (KI) at a concentration of 100 mM when added to microbial cells (10

Indexed as

Anti-Bacterial AgentsCandida albicansDihematoporphyrin EtherDrug SynergismGram-Negative BacteriaMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsPhotosensitizing AgentsPotassium IodideAnti-Bacterial AgentsDihematoporphyrin EtherPhotosensitizing AgentsPotassium Iodideantimicrobial photodynamic inactivationGram-negative bacteriaPhotofrinpotassium iodidereactive iodine speciessinglet oxygen

Identifiers

PMID28207234
PMCPMC5528003
OpenAlexW2588260342

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.