ArticleJournal of experimental botany2017
Identification of critical functional residues of receptor-like kinase ERECTA.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Advances in ERECTA Family Regulation of Female Gametophyte Development inPlants (Basel, Switzerland) · 2025Review
- Preventing inappropriate signals pre- and post-ligand perception by a toggle switch mechanism of ERECTA.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Preventing Inappropriate Signals Pre- and Post-Ligand Perception by a Toggle-Switch Mechanism of ERECTA.bioRxiv : the preprint server for biology · 2024Article
- Allosteric activation of the co-receptor BAK1 by the EFR receptor kinase initiates immune signaling.eLife · 2024Article
- TomatoFrontiers in plant science · 2023Article
- ERECTA regulates seed size independently of its intracellular domain via MAPK-DA1-UBP15 signaling.The Plant cell · 2022Article
- Initiation of aboveground organ primordia depends on combined action of auxin, ERECTA family genes, and PINOID.Plant physiology · 2022Article
- Identification of Key Residues Essential for the Activation of Plant Immunity by Subtilisin FromFrontiers in microbiology · 2022Article
- Enhanced biomass and thermotolerance ofPeerJ · 2022Article
- Shouting out loud: signaling modules in the regulation of stomatal development.Plant physiology · 2021Review
- Modification of soybean growth and abiotic stress tolerance by expression of truncated ERECTA protein from Arabidopsis thaliana.PloS one · 2020Article
- EPFL Signals in the Boundary Region of the SAM Restrict Its Size and Promote Leaf Initiation.Plant physiology · 2019Article
- Variable Effects of C-Terminal Fusions on FLS2 Function: Not All Epitope Tags Are Created Equal.Plant physiology · 2018Article
- Phylogenetic and CRISPR/Cas9 Studies in Deciphering the Evolutionary Trajectory and Phenotypic Impacts of RiceFrontiers in plant science · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plants, extracellular signals are primarily sensed by plasma membrane-localized receptor-like kinases (RLKs). ERECTA is a leucine-rich repeat RLK that together with its paralogs ERECTA-like 1 (ERL1) and ERL2 regulates multiple aspects of plant development. ERECTA forms complexes with a range of co-receptors and senses secreted cysteine-rich small proteins from the EPF/EPFL family. Currently the mechanism of the cytoplasmic domain activation and transmission of the signal by ERECTA is unclear. To gain a better understanding we performed a structure-function analysis by introducing altered ERECTA genes into erecta and erecta erl1 erl2 mutants. These experiments indicated that ERECTA's ability to phosphorylate is functionally significant, and that while the cytoplasmic juxtamembrane domain is important for ERECTA function, the C-terminal tail is not. An analysis of multiple putative phosphorylation sites identified four amino acids in the activation segment of the kinase domain as functionally important. Homology of those residues to functionally significant amino acids in multiple other plant RLKs emphasizes similarities in RLK function. Specifically, our data predicts Thr812 as a primary site of phosphor-activation and potential inhibitory phosphorylation of Tyr815 and Tyr820. In addition, our experiments suggest that there are differences in the molecular mechanism of ERECTA function during regulation of stomata development and in elongation of above-ground organs.
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