ArticleCell death & disease2017
ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial function.
Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- ID2-ETS2 axis regulates the transcriptional acquisition of pro-tumoral microglia phenotype in glioma.Cell death & disease · 2024Article
- Article
- The NRF2/ID2 Axis in Vascular Smooth Muscle Cells: Novel Insights into the Interplay between Vascular Calcification and Aging.Aging and disease · 2024Article
- ID2 Promotes Lineage Transition of Prostate Cancer through FGFR and JAK-STAT Signaling.Cancers · 2024Article
- The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade.Frontiers in cell and developmental biology · 2023Review
- ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation.Scientific reports · 2022Article
- Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Id2 exerts tumor suppressor properties in lung cancer through its effects on cancer cell invasion and migration.Frontiers in oncology · 2022Article
- GRPEL2 Knockdown Exerts Redox Regulation in Glioblastoma.International journal of molecular sciences · 2021Article
- Cell aging related genes can be used to characterize clinical prognoses and further stratify diffuse gliomas.Scientific reports · 2021Article
- Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines.Oncotarget · 2020Article
- Transcriptome-wide analysis associates ID2 expression with combined pre- and post-capillary pulmonary hypertension.Scientific reports · 2019Article
- Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas.Acta neuropathologica communications · 2019Article
- Fostering open collaboration in drug development for paediatric brain tumours.Biochemical Society transactions · 2019Review
- A recombinant lentiviral PDGF-driven mouse model of proneural glioblastoma.Neuro-oncology · 2018Article
- The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate.The Journal of biological chemistry · 2017Article
- Cpt1c regulated by AMPK promotes papillary thyroid carcinomas cells survival under metabolic stress conditions.Journal of Cancer · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor cells proliferate in cellular environments characterized by a lack of optimal tissue organization resulting oftentimes in compromised cellular metabolism affecting nutrition, respiration, and energetics. The response of tumor cells to adverse environmental conditions is a key feature affecting their pathogenicity. We found that inhibitor of DNA binding 2 (ID2) expression levels significantly correlate with the ability of glioblastoma (GBM)-derived cell lines to survive glucose deprivation. ID2 suppressed mitochondrial oxidative respiration and mitochondrial ATP production by regulating the function of mitochondrial electron transport chain (mETC) complexes, resulting in reduced superoxide and reactive oxygen species (ROS) production from mitochondria. ID2 suppression of ROS production reduced mitochondrial damage and enhanced tumor cell survival during glucose deprivation. Bioinformatics analysis of GBM gene expression data from The Cancer Genome Atlas (TCGA) database revealed that expression of ID2 mRNA is unique among ID gene family members in correlating with the expression of nuclear genes involved in mitochondrial energy metabolism and assembly of mETC. Our data indicate that the expression level of ID2 in GBM cells can predict the sensitivity of GBM-derived tumor cells to decreased glucose levels. Low levels of ID2 expression in human GBM tissues may identify a clinical group in which metabolic targeting of glycolytic pathways can be expected to have the greatest therapeutic efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.