ArticleCell death & disease2017
In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells.
Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Evaluating Alkaline Phosphatase-Instructed Self-Assembly of d‑Peptide Diesters for Selectively Inhibiting Immunosuppressive Cancer Cells.ACS omega · 2026Article
- Cryo-Structural Insights into Enzymatic Peptide Self-Assembly Driving Extrinsic Lytic Cell Death.Journal of the American Chemical Society · 2026Article
- Intrinsically Disordered Peptide Nanofibers from a Structured Motif Within Proteins.Angewandte Chemie (International ed. in English) · 2025Article
- Advances in Enzyme-responsive SupramolecularCurrent drug delivery · 2025Review
- Enzymatic control of intermolecular interactions for generating synthetic nanoarchitectures in cellular environment.Science and technology of advanced materials · 2024Review
- Different types of cell death and their shift in shaping disease.Cell death discovery · 2023Review
- Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications.Molecules (Basel, Switzerland) · 2022Review
- Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death.Acta pharmaceutica Sinica. B · 2022Article
- Enzymatic noncovalent synthesis of peptide assemblies generates multimolecular crowding in cells for biomedical applications.Chemical communications (Cambridge, England) · 2021Review
- Phosphobisaromatic motifs enable rapid enzymatic self-assembly and hydrogelation of short peptides.Soft matter · 2021Article
- Enzymatically Forming Cell Compatible Supramolecular Assemblies of Tryptophan-Rich Short Peptides.Peptide science (Hoboken, N.J.) · 2021Article
- Trypsin-Instructed Self-Assembly on Endoplasmic Reticulum for Selectively Inhibiting Cancer Cells: Dedicated to Professor George M. Whitesides on the occasion of his 80th birthday.Advanced healthcare materials · 2021Article
- Heterotypic Supramolecular Hydrogels Formed by Noncovalent Interactions in Inflammasomes.Molecules (Basel, Switzerland) · 2020Article
- Enzymatic Noncovalent Synthesis.Chemical reviews · 2020Review
- Enzyme-Instructed Self-Assembly for Cancer Therapy and Imaging.Bioconjugate chemistry · 2020Review
- Probing Reversible Guest Binding with HyperpolarizedMolecules (Basel, Switzerland) · 2020Review
- Enzymatic Noncovalent Synthesis of Supramolecular Soft Matter for Biomedical Applications.Matter · 2019Article
- Article
- Assemblies of Peptides in a Complex Environment and their Applications.Angewandte Chemie (International ed. in English) · 2019Review
- Instructed Assembly of Peptides for Intracellular Enzyme Sequestration.Journal of the American Chemical Society · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Nanofibrils of small molecules, as a new class of biofunctional entities, exhibit emergent properties for controlling cell fates, but the relevant mechanism remains to be elucidated and the in vivo effect has yet to be examined. Here, we show that D-peptide nanofibrils, generated by enzyme-instructed self-assembly (EISA), pleiotropically activate extrinsic death signaling for selectively killing cancer cells. Catalyzed by alkaline phosphatases and formed in situ on cancer cells, D-peptide nanofibrils present autocrine proapoptotic ligands to their cognate receptors in a juxtacrine manner, as well as directly cluster the death receptors. As multifaceted initiators, D-peptide nanofibrils induce apoptosis of cancer cells without harming normal cells in a co-culture, kill multidrug-resistant (MDR) cancer cells, boost the activities of anticancer drugs, and inhibit tumor growth in a murine model. Such a supramolecular cellular biochemical process (consisting of reaction, assembly, and binding) for multi-targeting or modulating protein-protein interaction networks ultimately may lead to new ways for combating cancer drug resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.