Evidence map›Paper›PMID 28206965›Full record

SynthesisOncotarget2017

Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis.

Yongzhao Zhao, Guangyan Si, Fengshang Zhu, Jialiang Hui, Shangli Cai, Chenshen Huang, Sijin Cheng, Abdel Hamid Fathy, Yi Xiang, Jing Li

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  12. Preoperative Predictors of Early Recurrence After Liver Resection for Multifocal Hepatocellular Carcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
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  20. Role of lncRNA-ATB in ovarian cancer and its mechanisms of action.Experimental and therapeutic medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yongzhao ZhaoSchool of Medicine, Tongji University, Shanghai, China.
Guangyan SiDepartment of Interventional Radiology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Fengshang ZhuDepartment of Gastroenterology, Tongji Hospital, Tongji University, Shanghai, China.
Jialiang HuiDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Shangli CaiMental Health Institute of the Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Hunan, China.
Chenshen HuangSchool of Medicine, Tongji University, Shanghai, China.
Sijin ChengSchool of Medicine, Tongji University, Shanghai, China.
Abdel Hamid FathySchool of Medicine, Tongji University, Shanghai, China.
Yi XiangDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jing LiDepartment of Gastroenterology, Tongji Hospital, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSeveral studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic significance of PLR in patients with HCC.

resultsA total of 10 studies involving a total of 2,315 patients were identified. The Newcastle-Ottawa Quality Assessment Scale (NOS) of each included study was greater than or equal to 5. The results indicated that high PLR was significantly associated with a worse OS when compared to the low PLR (HR = 1.60, 95% CI = 1.23-2.08, p = 0.0005; I2 = 88%, p < 0.00001). Similar results were detected in the subgroup analysis of the analysis model, cut-off value, ethnicity, sample size and therapy. However, no obvious correlation between the PLR and DFS/RFS in patients with HCC was observed (HR = 1.21, 95% CI = 0.87-1.67, p = 0.26; I2 = 61%, p = 0.07). MATERIALS AND

methodsA complete literature search in the PubMed, Cochrane Library and Embase database was performed. Retrospective and prospective studies focusing on the role of PLR on the prognosis in HCC were all deemed as "suitable" for our scope. The endpoints determined were: the overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and the progress free survival (PFS).

conclusionsThe study revealed that high PLR is an unfavorable predictor of OS in patients with HCC, and high PLR is a promising prognostic biomarker for HCC, especially for patients in Asia.

Indexed as

Carcinoma, HepatocellularDisease-Free SurvivalFemaleHumansLiver NeoplasmsLymphocyte CountPlatelet CountPrognosisSurvival Analysishepatocellular carcinomaoverall survivalplatelet to lymphocyte ratioprognostic

Identifiers

PMID28206965
PMCPMC5410268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.