ArticleNeuropsychology2017
Cognitive control and associated neural correlates in adults with spina bifida myelomeningocele.
Article in Neuropsychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Variation in Neurodegeneration-Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida.Annals of the Child Neurology Society · 2025Article
- Memory in Spina Bifida, from Childhood to Adulthood: A Systematic Review.Journal of clinical medicine · 2024Review
- A scoping review of cognition in spina bifida and its consequences for activity and participation throughout life.Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Cognitive function and performance of everyday activities in adults with spina bifida.Journal of rehabilitation medicine · 2021Article
- Assessment of Health Literacy and Self-reported Readiness for Transition to Adult Care Among Adolescents and Young Adults With Spina Bifida.JAMA network open · 2021Article
- Cognitive and motor function in adults with spina bifida myelomeningocele: a pilot study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Psychological morbidity among adults with cerebral palsy and spina bifida.Psychological medicine · 2021Article
- Review on myelomeningocele management and its current status in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2019Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAccelerated aging can occur in adult survivors of neurodevelopmental disorders, but has been narrowly studied in spina bifida myelomeningocele (SBM). Since discrete aspects of cognitive control and related neural network macrostructure deteriorate in normal aging, the specificity and trajectory of cognition and neuropathology incurred across adulthood in SBM were examined.
methodAdults (N = 120) with and without SBM completed working memory span and manipulation tasks, and an inhibitory control task. A subset (n = 53) underwent structural MRI. Effects of group, age, and their interaction on performance and select gray matter volumes were examined.
resultsAdults with SBM had significantly poorer working memory accuracy and overall inhibitory control performance than typical peers. Age negatively predicted inhibitory control. Group × Age significantly interacted on span accuracy; advanced age related to diminished performance in typical adults, but not in adults with SBM. SBM related to disproportionately enlarged cortical and putamen and reduced hippocampus volumes. Group × Age significantly interacted on cortical, but not subcortical gray matter volumes. Dorsolateral prefrontal, hippocampus, and putamen volumes negatively correlated with cognitive performance.
conclusionsSupporting previous literature, current findings elucidated a profile of executive impairment in SBM that was maintained in a parallel maturational trajectory to typical aging. Accelerated aging in cognitive control or subcortical gray matter was not supported in SBM. However, reductions in anterior and posterior cortical regions were exacerbated in older adults with SBM compared with typical peers. Overall results supported persistent anomalous neurodevelopmental maturation across the life span in SBM that related to diminished cognitive control. (PsycINFO Database Record
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