ArticleMolecular ecology2017
Plasmid and clonal interference during post horizontal gene transfer evolution.
Article in Molecular ecology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- The leading region of many plasmids is adapted for translational efficiency.Nucleic acids research · 2026Article
- Putting BASIL in a BLT: A Bayesian filtering method for estimating the fitness effects of nascent adaptive mutations.PLoS computational biology · 2026Article
- Fitness costs and persistence of plasmid-mediated cephalosporin resistance inFrontiers in microbiology · 2026Review
- Intracellular competition shapes plasmid population dynamics.Science (New York, N.Y.) · 2025Article
- Mechanistic insights into the formation and spread of carbapenem-resistant hypervirulentMicrobial genomics · 2025Article
- Plasmid copy number as a modulator in bacterial pathogenesis and antibiotic resistance.npj antimicrobials and resistance · 2025Review
- Assessment of plasmids for relating the 2020 Salmonella enterica serovar Newport onion outbreak to farms implicated by the outbreak investigation.BMC genomics · 2023Article
- The community ecology perspective of omics data.Microbiome · 2022Article
- Plasmid Viability Depends on the Ecological Setting of Hosts within a Multiplasmid Community.Microbiology spectrum · 2022Article
- Symbiosis Contribution of Non-nodulating Bradyrhizobium cosmicum S23321 after Transferal of the Symbiotic Plasmid pDOA9.Microbes and environments · 2022Article
- Beyond horizontal gene transfer: the role of plasmids in bacterial evolution.Nature reviews. Microbiology · 2021Review
- Evolutionary responses to codon usage of horizontally transferred genes inMicrobial genomics · 2021Article
- Intracellular Competitions Reveal Determinants of Plasmid Evolutionary Success.Frontiers in microbiology · 2020Article
- A High-Resolution View of Adaptive Event Dynamics in a Plasmid.Genome biology and evolution · 2019Article
- Segregational Drift and the Interplay between Plasmid Copy Number and Evolvability.Molecular biology and evolution · 2019Article
- Evolutionary Changes after Translational Challenges Imposed by Horizontal Gene Transfer.Genome biology and evolution · 2019Article
- Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation.Nature ecology & evolution · 2018Article
- Assessing the benefits of horizontal gene transfer by laboratory evolution and genome sequencing.BMC evolutionary biology · 2018Article
- The parA Region of Broad-Host-Range PromA Plasmids Is a Carrier of Mobile Genes.Microbial ecology · 2018Article
- Sampling the mobile gene pool: innovation via horizontal gene transfer in bacteria.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Plasmids are nucleic acid molecules that can drive their own replication in a living cell. They can be transmitted horizontally and can thrive in the host cell to high-copy numbers. Plasmid replication and gene expression consume cellular resources and cells carrying plasmids incur fitness costs. But many plasmids carry genes that can be beneficial under certain conditions, allowing the cell to endure in the presence of antibiotics, toxins, competitors or parasites. Horizontal transfer of plasmid-encoded genes can thus instantaneously confer differential adaptation to local or transient selection conditions. This conflict between cellular fitness and plasmid spread sets the scene for multilevel selection processes. We have engineered a system to study the short-term evolutionary impact of different synonymous versions of a plasmid-encoded antibiotic resistance gene. Applying experimental evolution under different selection conditions and deep sequencing allowed us to show rapid local adaptation to the presence of antibiotic and to the specific version of the resistance gene transferred. We describe the presence of clonal interference at two different levels: at the within-cell level, because a single cell can carry several plasmids, and at the between-cell level, because a bacterial population may contain several clones carrying different plasmids and displaying different fitness in the presence/absence of antibiotic. Understanding the within-cell and between-cell dynamics of plasmids after horizontal gene transfer is essential to unravel the dense network of mobile elements underlying the worldwide threat to public health of antibiotic resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.