ArticleAddiction (Abingdon, England)2017
Working memory ability and early drug use progression as predictors of adolescent substance use disorders.
Article in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05879198 (Train Your Brain), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Train Your Brain: A Pilot Project to Improve Memory and Decision Making to Improve Outcomes Among Youth
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- A systematic review and meta-analysis of delay discounting and cannabis use.Experimental and clinical psychopharmacology · 2021Pooled it
- Working Memory Training Reduces Cigarette Smoking Among Low-Income Individuals With Elevated Delay Discounting.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Trial
- Working memory training and high magnitude incentives for youth cannabis use: A SMART pilot trial.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Trial
- Identifying significant environmental predictors of change in delay discounting among adolescents in the Adolescent Brain Cognitive Development Study.Experimental and clinical psychopharmacology · 2026Article
- Divergent disinhibition profiles linked to externalizing psychopathology.Journal of psychopathology and clinical science · 2026Article
- Untangling relationships between cognitive development and child and adolescent mental health: Findings from the ABCD Study.Developmental cognitive neuroscience · 2026Review
- From Pellets to Prizes: Preclinical and Clinical Perspectives on Contingency Management for the Treatment of Substance Use Disorder.Substance abuse and rehabilitation · 2026Review
- Child maltreatment and executive function development throughout adolescence and into young adulthood.Development and psychopathology · 2025Article
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- Dissociable Contributions of Goal-Relevant Evidence and Goal-Irrelevant Familiarity to Individual and Developmental Differences in Conflict Recognition.Cognitive science · 2024Article
- Neurocognitive Markers during Maximum Alcohol Use in Late Adolescence as Predictors of Change in Later Drinking Behaviors.Mental health science · 2024Article
- Associations Between Family History of Alcohol and/or Substance Use Problems and Frontal Cortical Development From 9 to 13 Years of Age: A Longitudinal Analysis of the ABCD Study.Biological psychiatry global open science · 2024Article
- Childhood stress, gender, and cognitive control: Midline theta power.Journal of psychiatric research · 2024Article
- Transactional Linkages Between Parenting Behaviors and Child Executive Functions and Self-Regulation from Early Childhood to Adolescence.Journal for person-oriented research · 2024Article
- Identifying Game-Based Digital Biomarkers of Cognitive Risk for Adolescent Substance Misuse: Protocol for a Proof-of-Concept Study.JMIR research protocols · 2023Article
- Value-based decision-making network functional connectivity correlates with substance use and delay discounting behaviour among young adults.NeuroImage. Clinical · 2023Article
- Developmental trajectories of delay discounting from childhood to young adulthood: longitudinal associations and test-retest reliability.Cognitive psychology · 2022Article
- Cascades From Early Adolescent Impulsivity to Late Adolescent Antisocial Personality Disorder and Alcohol Use Disorder.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2022Article
- Risky decision-making as an antecedent or consequence of adolescent cannabis use: findings from a 2-year longitudinal study.Addiction (Abingdon, England) · 2022Article
- An assessment of executive function in two different rat models of attention-deficit hyperactivity disorder: Spontaneously hypertensive versus Lphn3 knockout rats.Genes, brain, and behavior · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
aimsTo test a neurobehavioral model of adolescent substance use disorder (SUD) resulting from an imbalance between a hyperactive reward motivation system and a hypoactive executive control system. Specifically, we tested (1) if early weakness in working memory (WM) and associated imbalance indicators of acting-without-thinking (AWT) and delay discounting (DD) predict SUD in late adolescence and (2) if early drug use progression mediates this relation.
designFive waves of longitudinal data collected annually from 2005 to 2010, with a final follow-up in 2012. SETTING AND
participantsSample of 387 community adolescents (baseline ages 11-13 years) recruited from the Philadelphia, PA, USA area. MEASUREMENTS: WM was assessed at baseline using four different computerized tasks. AWT and DD were assessed at baseline using self-reports. Early drug use patterns were modeled using annual self-reports of recent drug use across the first four waves. Final outcome of SUD was assessed at last wave using self-reports matched to the DSM-5 criteria for three commonly used substances: alcohol, marijuana and tobacco.
findingsWeakness in WM at baseline, associated with neurobehavioral imbalance indicators of AWT, B (SE) = -0.06 (0.02), P < 0.01 and DD, B (SE) = -7.30 (1.93), P < 0.01, was a significant predictor of SUD at final follow-up. WM predicted SUD both independent of early drug use, B (SE) = 0.08 (0.03), P < 0.05, and as mediated by early drug use progression, B (SE) = -0.06 (0.02), P < 0.01.
conclusionsAdolescents with weak working memory have less control over impulsive urges, placing them at risk for later substance use disorder with some of the effects mediated by early drug use progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.