ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Cardiovascular Complications and Short-term Mortality Risk in Community-Acquired Pneumonia.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07708610 (Preadmission GLP-1 Receptor Agonist Plus SGLT2 Inhibitor Use and Early Outcomes After Pneumonia Hospitalization in Adults With Type 2 Diabetes), which is not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preadmission GLP-1 Receptor Agonist Plus SGLT2 Inhibitor Use and Early Outcomes After Pneumonia Hospitalization in Adults With Type 2 Diabetes: A Target Trial Emulation
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 217 citations in OpenAlex.
- Prevalence of new-onset atrial fibrillation in hospitalized patients with community-acquired pneumonia: a systematic review and meta-analysis.Internal and emergency medicine · 2023Pooled it
- Systematic review and meta-analysis of the effectiveness and safety of hydroxychloroquine in treating COVID-19 patients.Journal of the Chinese Medical Association : JCMA · 2021Pooled it
- Hypercoagulation and Antithrombotic Treatment in Coronavirus 2019: A New Challenge.Thrombosis and haemostasis · 2020Pooled it
- Cardiovascular complications after pleural infection: incidences, risk factors, and prognostic relevance.BMC cardiovascular disorders · 2026Article
- The cumulative incidence of atrial fibrillation in the hospitalized medical patient: a systematic review and meta-analysis.European heart journal open · 2026Review
- Predictors of secondary cardiovascular events in older adults with community-acquired pneumonia: a prospective observational study.Clinics (Sao Paulo, Brazil) · 2026Article
- Non-antimicrobial interventions in recovery from community-acquired pneumonia in adults.Current opinion in infectious diseases · 2026Review
- Trends and Disparities in Ischemic Heart Disease and Pneumonia Associated Mortality in the United States: A Population-Based Retrospective Analysis of Death Records From 1999 to 2023.Journal of epidemiology and global health · 2026Article
- Clinical outcomes in hospitalized patients with community-acquired pneumonia: A comprehensive analysis of associated factors.PloS one · 2026Article
- Association Between Long-Term Glycemic Control and Clinical Outcomes in Patients With Diabetes Mellitus Hospitalized for Lower Respiratory Tract Infections: A Retrospective Cohort Study.Journal of diabetes research · 2026Observational
- Cardiac Manifestations of Mycoplasma pneumoniae Infections: A Cohort Study 2007-2024.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Article
- S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease.Experimental & molecular medicine · 2025Article
- Vaccination in Patients with Cardiovascular Disease: A Case-Based Approach and Contemporary Review.CJC open · 2025Review
- Review
- Article
- The Risk of Adverse Cardiac Events after Pneumonia in Patients with Coronary Artery Disease.Annals of the American Thoracic Society · 2025Article
- Infection-Related Hospitalization and Incident Heart Failure: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2025Article
- Emergency planned re-infusion therapy and hospitalisation for community-acquired pneumonia: a retrospective case-control study.Journal of global health · 2025Article
- Immune mediators in heart-lung communication.Pflugers Archiv : European journal of physiology · 2025Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issuedErratum.2017
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND.: Previous reports suggest that community-acquired pneumonia (CAP) is associated with an enhanced risk of cardiovascular complications. However, a contemporary and comprehensive characterization of this association is lacking. METHODS.: In this multicenter study, 1182 patients hospitalized for CAP were prospectively followed for up to 30 days after their hospitalization for this infection. Study endpoints included myocardial infarction, new or worsening heart failure, atrial fibrillation, stroke, deep venous thrombosis, cardiovascular death, and total mortality. RESULTS.: Three hundred eighty (32.2%) patients experienced intrahospital cardiovascular events (CVEs) including 281 (23.8%) with heart failure, 109 (9.2%) with atrial fibrillation, 89 (8%) with myocardial infarction, 11 (0.9%) with ischemic stroke, and 1 (0.1%) with deep venous thrombosis; 28 patients (2.4%) died for cardiovascular causes. Multivariable Cox regression analysis showed that intrahospital Pneumonia Severity Index (PSI) class (hazard ratio [HR], 2.45, P = .027; HR, 4.23, P < .001; HR, 5.96, P < .001, for classes III, IV, and V vs II, respectively), age (HR, 1.02, P = .001), and preexisting heart failure (HR, 1.85, P < .001) independently predicted CVEs. One hundred three (8.7%) patients died by day 30 postadmission. Thirty-day mortality was significantly higher in patients who developed CVEs compared with those who did not (17.6% vs 4.5%, P < .001). Multivariable Cox regression analysis showed that intrahospital CVEs (HR, 5.49, P < .001) independently predicted 30-day mortality (after adjustment for age, PSI score, and preexisting comorbid conditions). CONCLUSIONS.: CVEs, mainly those confined to the heart, complicate the course of almost one-third of patients hospitalized for CAP. More importantly, the occurrence of CVEs is associated with a 5-fold increase in CAP-associated 30-day mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.