ArticleScientific reports2017
Does Zika virus infection affect mosquito response to repellents?
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- A critical review of current laboratory methods used to evaluate mosquito repellents.Frontiers in insect science · 2024Review
- Do Commercial Insect Repellents Provide Protection against the TickPathogens (Basel, Switzerland) · 2023Article
- Influence of RVFV Infection on Olfactory Perception and Behavior inPathogens (Basel, Switzerland) · 2023Article
- A highly expressed odorant receptor from the yellow fever mosquito, AaegOR11, responds to (+)- and (-)-fenchone and a phenolic repellent.Insect biochemistry and molecular biology · 2022Article
- Mosquito odorant receptor sensitive to natural spatial repellents and inhibitory compounds.Insect biochemistry and molecular biology · 2022Article
- Modulation of odour-guided behaviour in mosquitoes.Cell and tissue research · 2021Review
- DEET and other repellents are inhibitors of mosquito odorant receptors for oviposition attractants.Insect biochemistry and molecular biology · 2019Article
- Odorant receptors from Culex quinquefasciatus and Aedes aegypti sensitive to floral compounds.Insect biochemistry and molecular biology · 2019Article
- Odorant Inhibition in Mosquito Olfaction.iScience · 2019Article
- A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET.PloS one · 2019Article
- Methyl dihydrojasmonate and lilial are the constituents with an "off-label" insect repellence in perfumes.PloS one · 2018Article
- Attraction of Culex mosquitoes to aldehydes from human emanations.Scientific reports · 2017Article
- Impact of Zika virus for infertility specialists: current literature, guidelines, and resources.Journal of assisted reproduction and genetics · 2017Review
- DEET as a feeding deterrent.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
The World Health Organization (WHO) recommends that people travelling to or living in areas with Zika virus (ZIKV) outbreaks or epidemics adopt prophylactic measures to reduce or eliminate mosquito bites, including the use of insect repellents. It is, however, unknown whether repellents are effective against ZIKV-infected mosquitoes, in part because of the ethical concerns related to exposing a human subject's arm to infected mosquitoes in the standard arm-in-cage assay. We used a previously developed, human subject-free behavioural assay, which mimics a human subject to evaluate the top two recommended insect repellents. Our measurements showed that DEET provided significantly higher protection than picaridin provided against noninfected, host-seeking females of the southern house mosquito, Culex quinquefasciatus, and the yellow fever mosquito, Aedes aegypti. When tested at lower doses, we observed a significant reduction in DEET-elicited protection against ZIKV-infected yellow fever mosquitoes from old and recent laboratory colonies. The reduction in protection is more likely associated with aging than the virus infection and could be compensated by applying a 5x higher dose of DEET. A substantial protection against ZIKV-infected and old noninfected mosquitoes was achieved with 5% DEET, which corresponds approximately to a 30% dose in the conventional arm-in-cage assays.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.