Evidence map›Paper›PMID 28205593›Full record

ArticleScientific reports2017

Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine.

Jacob M Hooker, Martin G Strebl, Frederick A Schroeder, Hsiao-Ying Wey, Amrut V Ambardekar, Timothy A McKinsey, Matthias Schoenberger

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Sequential Ir/Cu-Mediated Method for theJournal of the American Chemical Society · 2021
    Article
  3. In Vivo [ACS chemical neuroscience · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jacob M HookerHarvard Medical School, Massachusetts General Hospital, Martinos Center for Biomedical Imaging, 149 13th Street, 02129 Charlestown, MA, USA.
Martin G StreblHarvard Medical School, Massachusetts General Hospital, Martinos Center for Biomedical Imaging, 149 13th Street, 02129 Charlestown, MA, USA.
Frederick A SchroederHarvard Medical School, Massachusetts General Hospital, Martinos Center for Biomedical Imaging, 149 13th Street, 02129 Charlestown, MA, USA.
Hsiao-Ying WeyHarvard Medical School, Massachusetts General Hospital, Martinos Center for Biomedical Imaging, 149 13th Street, 02129 Charlestown, MA, USA.
Amrut V AmbardekarDepartment of Medicine, Division of Cardiology and Consortium for Fibrosis Research and Translation, University of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Timothy A McKinseyDepartment of Medicine, Division of Cardiology and Consortium for Fibrosis Research and Translation, University of Colorado - Anschutz Medical Campus, Aurora, CO, USA.
Matthias SchoenbergerHarvard Medical School, Massachusetts General Hospital, Martinos Center for Biomedical Imaging, 149 13th Street, 02129 Charlestown, MA, USA.
Massachusetts General Hospital · USUniversity of Colorado Anschutz Medical Campus · USAthinoula A. Martinos Center for Biomedical Imaging · USHarvard University · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Regulation of Chromatin Signaling in Heart Failure by the BRD4 Bromodomain Protein.R01HL127240 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY, SRIVASTAVA, DEEPAK · 2015 to 2022
$6.4M
Regulation of Cardiac Signaling by Class I Histone DeacetylasesR01HL116848 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY · 2013 to 2021
$3.1M
Combined MRI/PET Imager for Simultaneous Acquisition of PET/MRI DataS10RR022976 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI JENKINS, BRUCE · 2007 to 2007
$2.0M
Inveon: A Triple Modality Biomedical Imaging SystemS10RR029495 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2010 to 2010
$1.3M
CYCLOTRON &RADIOCHEMISTRY: SUBSTANCE ABUSE, COCAINE, OPIOIDS10RR017208 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2004 to 2004
$500k
F-18 SynthesizerS10RR023452 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2007 to 2007
$500k
500 MHz NMR Spectrometer for Molecular Imaging ApplicationsS10RR023385 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2007 to 2007
$500k
Carbon-11 Radiopharmaceutical Production SystemS10RR026666 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2010 to 2010
$462k
Isoform-Selective HDAC Inhibitors for Age-Associated Diastolic DysfunctionR21AG043822 · NIA · UNIVERSITY OF COLORADO DENVER · PI MCKINSEY, TIMOTHY · 2012 to 2013
$414k
NCATS NIH HHS UL1 TR001082NCRR NIH HHS S10 RR017208NCRR NIH HHS S10 RR022976NCRR NIH HHS S10 RR023385NCRR NIH HHS S10 RR023452NCRR NIH HHS S10 RR026666NCRR NIH HHS S10 RR029495NHLBI NIH HHS R01 HL116848NHLBI NIH HHS R01 HL127240NIA NIH HHS R21 AG043822
6 · The paper itself

Abstract

The key function of the heart, a well-orchestrated series of contractions, is controlled by cardiac action potentials. These action potentials are initiated and propagated by a single isoform of voltage gated sodium channels - SCN5A. However, linking changes in SCN5A expression levels to human disease in vivo has not yet been possible. Radiocaine, an F-18 radiotracer for positron emission tomography (PET), is the first SCN5A imaging agent in the heart. Explants from healthy and failing human hearts were compared using radiocaine autoradiography to determine that the failing heart has ~30% lower SCN5A levels - the first evidence of changes in SCN5A expression in humans as a function of disease. Paving the way for translational imaging, radiocaine proved to exhibit high in vivo specific binding to the myocardium of non-human primates. We envision that SCN5A measurements using PET imaging may serve as a novel diagnostic tool to stratify arrhythmia risk and assess for progression of heart failure in patients with a broad spectrum of cardiovascular diseases.

Indexed as

Action PotentialsAnimalsArrhythmias, CardiacAutoradiographyDisease Models, AnimalFemaleFluorine RadioisotopesGene Expression RegulationGenetic Predisposition to DiseaseHeartHeart FailureHumansMaleMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelOrgan Culture TechniquesFluorine-18Fluorine RadioisotopesNAV1.5 Voltage-Gated Sodium ChannelRadiopharmaceuticalsSCN5A protein, human

Identifiers

PMID28205593
PMCPMC5311962
OpenAlexW2589062962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.