ArticleScientific reports2017
Accelerated biodegradation of silk sutures through matrix metalloproteinase activation by incorporating 4-hexylresorcinol.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
- Effect of antiseptic gels in the microbiologic colonization of the suture threads after oral surgery.Scientific reports · 2020Trial
- Clinical presentation, treatment, and outcomes for 15 dogs with two or three congenital extrahepatic portosystemic shunts.Veterinary surgery : VS · 2026Article
- Recent Advances in Silk Fibroin Derived fromJournal of functional biomaterials · 2025Review
- Assessment the properties of various surgical sutures.Scientific reports · 2025Article
- Suture Materials: Conventional and Stimulatory-Responsive Absorbable Polymers with Biomimetic Function.Biomimetics (Basel, Switzerland) · 2025Review
- Drug-Eluting Sutures by Hot-Melt Extrusion: Current Trends and Future Potentials.Materials (Basel, Switzerland) · 2023Review
- Article
- Resistance to Degradation of Silk Fibroin Hydrogels Exposed to Neuroinflammatory Environments.Polymers · 2023Article
- Multiple ways for the same destination: bone regeneration.Maxillofacial plastic and reconstructive surgery · 2022Review
- Angiogenic property of silk fibroin scaffolds with adipose-derived stem cells on chick chorioallantoic membrane.Royal Society open science · 2021Article
- Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation.Nanomaterials (Basel, Switzerland) · 2020Article
- 4-Hexylresorcinol-in duced angiogenesis potential in human endothelial cells.Maxillofacial plastic and reconstructive surgery · 2020Article
- Immunomodulation for maxillofacial reconstructive surgery.Maxillofacial plastic and reconstructive surgery · 2020Review
- Immunomodulation and smart materials for maxillofacial tissue engineering.Maxillofacial plastic and reconstructive surgery · 2020Article
- Microfibers synthesized by wet-spinning of chitin nanomaterials: mechanical, structural and cell proliferation properties.RSC advances · 2020Article
- Review
- 4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways.Scientific reports · 2019Article
- Quantitative Assessment of Antimicrobial Activity of PLGA Films Loaded with 4-Hexylresorcinol.Journal of functional biomaterials · 2018Article
- Comparison of Bio-degradation for Ridge Preservation Using Silk Fibroin-based Grafts and a Collagen Plug.Tissue engineering and regenerative medicine · 2017Article
- Long-term outcome after total scapulectomy for the treatment of osteosarcoma in a cat.JFMS open reportsArticle
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silk suture material is primarily composed of silk fibroin and regarded as a non-resorbable material. It is slowly degraded by proteolysis when it is implanted into the body. 4-Hexylresorcinol (4HR) is a well-known antiseptic. In this study, the biodegradability of 4HR-incorporated silk sutures were compared to that of untreated silk sutures and polyglactin 910 sutures, a commercially available resorbable suture. 4HR-incorporated silk sutures exhibited anti-microbial properties. Matrix metalloproteinase (MMP) can digest a wide spectrum of proteins. 4HR increased MMP-2, -3, and -9 expression in RAW264.7 cells. MMP-2, -3, and -9 were able to digest not only silk fibroin but also silk sutures. Consequently, 59.5% of the 4HR-incorporated silk suture material remained at 11 weeks after grafting, which was similar to that of polyglactin 910 degradation (56.4% remained). The residual amount of bare silk suture material at 11 weeks after grafting was 91.5%. The expression levels of MMP-2, -3 and -9 were high in the 4HR-incorporated silk suture-implanted site 12 weeks after implantation. In conclusion, 4HR-treated silk sutures exhibited anti-microbial properties and a similar level of bio-degradation to polyglactin 910 sutures and induced higher expression of MMP-2, -3, and -9 in macrophages.
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