ArticleScientific reports2017
Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Septo-Optic Dysplasia Plus with Bilateral Homonymous Hemianopia - Case Report.International medical case reports journal · 2025Article
- Optical coherence tomography and optical coherence tomography angiography findings in optic nerve hypoplasia and their relationships with visual acuity.Scientific reports · 2024Article
- Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents.Scientific reports · 2022Article
- Optical Coherence Tomography Can Predict Visual Acuity in Children with Optic Nerve Hypoplasia.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- The Clinical Contribution of Full-Field Electroretinography and 8-Year Experiences of Application in a Tertiary Medical Center.Journal of personalized medicine · 2021Article
- Genotype-Phenotype of Isolated Foveal Hypoplasia in a Large Cohort: Minor Iris Changes as an Indicator of PAX6 Involvement.Investigative ophthalmology & visual science · 2021Article
- Neural damage and neuroprotection with glaucoma development in aniridia.Current neurobiology · 2021Article
- Non-Cell Autonomous Roles for CASK in Optic Nerve Hypoplasia.Investigative ophthalmology & visual science · 2019Article
- Neuro-Ophthalmological Manifestations Of Septo-Optic Dysplasia: Current Perspectives.Eye and brain · 2019Review
- Foveal hypoplasia and optical coherence tomographic imaging.Taiwan journal of ophthalmologyReview
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were performed. SD-OCT analysis of the macular region showed significant ganglion cells complex (GCC) thinning nasally and temporally (P < 0.05), but the thickness from the inner nuclear layer (INL) to the retinal pigment epithelium (RPE) became thinner only nasally (P < 0.05). SD-OCT analysis of the circumpapillary region showed significant thinning in the retinal nerve fiber layer and from the INL to the RPE (P < 0.05). The horizontal SD-OCT images showed variable foveal abnormalities. FF-ERG analysis showed significantly reduced amplitudes (P < 0.05) and preserved implicit time in the photopic negative response. The amplitudes and implicit times of the other FF-ERG components did not differ significantly. FM-ERG analysis showed significantly reduced amplitudes (P < 0.05) but preserved implicit times in all components. The current study showed the change of retinal structure and function in eyes with ONH compared with those with control, representing by decreased retinal ganglion cells (RGCs) and their axons, foveal abnormalities, and preserved peripheral retina except for the RGCs and their axons.
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