ArticleNature communications2017
Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Cooperativity, entropy, and effective concentration in DNA origami self-replication.Science advances · 2026Article
- Construction of a COChemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Piggybacking functionalized DNA nanostructures into live-cell nuclei.Science advances · 2024Article
- Piggybacking functionalized DNA nanostructures into live cell nuclei.bioRxiv : the preprint server for biology · 2024Article
- Isothermal self-assembly of multicomponent and evolutive DNA nanostructures.Nature nanotechnology · 2023Article
- In vitro transcription of self-assembling DNA nanoparticles.Scientific reports · 2023Article
- Chemically programmable bacterial probes for the recognition of cell surface proteins.Materials today. Bio · 2023Article
- Functionalizing DNA origami to investigate and interact with biological systems.Nature reviews. Materials · 2023Article
- Single molecule DNA origami nanoarrays with controlled protein orientation.Biophysics reviews · 2022Article
- Visible wavelength spectral tuning of absorption and circular dichroism of DNA-assembled Au/Ag core-shell nanorod assemblies.Materials advances · 2022Article
- Proximity-enhanced synthesis of DNA-peptide-DNA triblock molecules.Chemical communications (Cambridge, England) · 2022Article
- Engineering Inorganic Materials with DNA Nanostructures.ACS central science · 2021Review
- Strategies to Build Hybrid Protein-DNA Nanostructures.Nanomaterials (Basel, Switzerland) · 2021Review
- Guest-protein incorporation into solvent channels of a protein host crystal (hostal).Acta crystallographica. Section D, Structural biology · 2021Article
- Design, assembly, and characterization of membrane-spanning DNA nanopores.Nature protocols · 2021Article
- Opportunities and challenges for the clinical translation of structured DNA assemblies as gene therapeutic delivery and vaccine vectors.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Insights into the Structure and Energy of DNA Nanoassemblies.Molecules (Basel, Switzerland) · 2020Review
- Challenges and Perspectives of DNA Nanostructures in Biomedicine.Angewandte Chemie (International ed. in English) · 2020Review
- Dynamic DNA Assemblies in Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The self-organizational properties of DNA have been used to realize synthetic hosts for protein encapsulation. However, current strategies of DNA-protein conjugation still limit true emulation of natural host-guest systems, whose formation relies on non-covalent bonds between geometrically matching interfaces. Here we report one of the largest DNA-protein complexes of semisynthetic origin held in place exclusively by spatially defined supramolecular interactions. Our approach is based on the decoration of the inner surface of a DNA origami hollow structure with multiple ligands converging to their corresponding binding sites on the protein surface with programmable symmetry and range-of-action. Our results demonstrate specific host-guest recognition in a 1:1 stoichiometry and selectivity for the guest whose size guarantees sufficient molecular diffusion preserving short intermolecular distances. DNA nanocontainers can be thus rationally designed to trap single guest molecules in their native form, mimicking natural strategies of molecular recognition and anticipating a new method of protein caging.
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