Evidence map›Paper›PMID 28205155›Full record

ReviewCurrent obesity reports2017

Endocrine Disruptors and Obesity.

Philippa D Darbre

Open access · hybridAbstract readReview
In one paragraph

Review in Current obesity reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 5 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 5 syntheses or guidelines pooled it, 377 citations in OpenAlex.

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  20. Mixtures ofToxics · 2025
    Article

97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Philippa D DarbreSchool of Biological Sciences, University of Reading, Reading, RG6 6UB, UK. p.d.darbre@reading.ac.uk.
University of Reading · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe purpose of this review was to summarise current evidence that some environmental chemicals may be able to interfere in the endocrine regulation of energy metabolism and adipose tissue structure. RECENT

findingsRecent findings demonstrate that such endocrine-disrupting chemicals, termed "obesogens", can promote adipogenesis and cause weight gain. This includes compounds to which the human population is exposed in daily life through their use in pesticides/herbicides, industrial and household products, plastics, detergents, flame retardants and as ingredients in personal care products. Animal models and epidemiological studies have shown that an especially sensitive time for exposure is in utero or the neonatal period. In summarising the actions of obesogens, it is noteworthy that as their structures are mainly lipophilic, their ability to increase fat deposition has the added consequence of increasing the capacity for their own retention. This has the potential for a vicious spiral not only of increasing obesity but also increasing the retention of other lipophilic pollutant chemicals with an even broader range of adverse actions. This might offer an explanation as to why obesity is an underlying risk factor for so many diseases including cancer.

Indexed as

AdipocytesAdipogenesisAnimalsAppetiteEndocrine DisruptorsEndocrine System DiseasesFemaleFood PreferencesHealth StatusHumansMice, ObeseObesityOrganic ChemicalsPPAR gammaPregnancyPrenatal Exposure Delayed EffectsEndocrine DisruptorsOrganic ChemicalsPPAR gammaReceptors, Aryl HydrocarbonReceptors, SteroidAdipogenesisBisphenol ADiethylstilbestrolEndocrine-disrupting chemicalsEndocrine disruptorObesityObesogenParabenPeroxisome proliferator-activated receptorPersistent organic pollutantsTributyltin

Identifiers

PMID28205155
PMCPMC5359373
OpenAlexW2588105018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.